Petersen O H
MRC Group, Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, UK.
Braz J Med Biol Res. 2009 Jan;42(1):9-16. doi: 10.1590/s0100-879x2009000100003.
The pancreatic acinar cell is a classical model for studies of secretion and signal transduction mechanisms. Because of the extensive endoplasmic reticulum and the large granular compartment, it has been possible--by direct measurements--to obtain considerable insights into intracellular Ca2+ handling under both normal and pathological conditions. Recent studies have also revealed important characteristics of stimulus-secretion coupling mechanisms in isolated human pancreatic acinar cells. The acinar cells are potentially dangerous because of the high intra-granular concentration of proteases, which become inappropriately activated in the human disease acute pancreatitis. This disease is due to toxic Ca2+ signals generated by excessive liberation of Ca2+ from both the endoplasmic reticulum and the secretory granules.
胰腺腺泡细胞是研究分泌和信号转导机制的经典模型。由于其内质网广泛且颗粒区室较大，通过直接测量，得以在正常和病理条件下深入了解细胞内钙离子的处理情况。最近的研究还揭示了分离的人胰腺腺泡细胞中刺激-分泌偶联机制的重要特征。腺泡细胞具有潜在危险性，因为其颗粒内蛋白酶浓度很高，而这些蛋白酶在人类疾病急性胰腺炎中会被不适当激活。这种疾病是由于内质网和分泌颗粒中钙离子过度释放产生的毒性钙离子信号所致。
