Hsiao Wayland, Anastasia Katrina, Hall John, Goodman Michael, Rimland David, Ritenour Chad W M, Issa Muta M
Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA.
ScientificWorldJournal. 2009 Feb 15;9:102-8. doi: 10.1100/tsw.2009.20.
It is estimated that 1.2 million Americans are infected with HIV. With advances in treatment and improved survival, HIV-positive patients are increasingly reaching an age when prostate cancer becomes a health issue. While there have been some reports in the literature reporting lower incidence of prostate cancer in HIV population cohorts, these studies have focused on younger populations, where we expect a lower incidence of prostate cancer. Our study involves patients over a 5.5 year period from a busy referral Veterans Medical Center referred to our urology clinic with either elevated PSA or abnormal DRE. Of these patients referred to our clinic, there is a markedly higher rate of prostate cancer in HIV patients when compared to our HIV-negative or HIV-unknown population. Though one may surmise a referral bias, in our highly regulated system, we use identical referral criterion for both HIV-positive and HIV-negative patients. Though this is a study with admittedly limited numbers, we believe this report is important because it is one of the first studies to address prostate cancer in a older cohort of patients who are referred because of suspicion for prostate cancer.
据估计，有120万美国人感染了艾滋病毒。随着治疗方法的进步和生存率的提高，艾滋病毒呈阳性的患者越来越多地达到前列腺癌成为健康问题的年龄。虽然文献中有一些报告称艾滋病毒人群队列中前列腺癌的发病率较低，但这些研究集中在较年轻的人群，而我们预计这一年龄段前列腺癌的发病率较低。我们的研究涉及在5.5年期间从一家繁忙的转诊退伍军人医疗中心转至我们泌尿外科诊所的患者，这些患者的前列腺特异性抗原（PSA）升高或直肠指检（DRE）异常。在转诊到我们诊所的这些患者中，与艾滋病毒呈阴性或艾滋病毒情况未知的人群相比，艾滋病毒患者中前列腺癌的发病率明显更高。尽管有人可能推测存在转诊偏差，但在我们高度规范的系统中，我们对艾滋病毒呈阳性和呈阴性的患者使用相同的转诊标准。尽管这是一项数量有限的研究，但我们认为本报告很重要，因为它是首批针对因怀疑患有前列腺癌而转诊的老年患者群体中的前列腺癌问题进行研究的报告之一。
