聚乳酸-Ⅰ型胶原混合纳米纤维支架对人间充质干细胞生长和成骨分化的特性研究
Characterization of a PLLA-collagen I blend nanofiber scaffold with respect to growth and osteogenic differentiation of human mesenchymal stem cells.
作者信息
Schofer Markus D, Boudriot Ulrich, Leifeld Irini, Sütterlin Romina I, Rudisile Markus, Wendorff Joachim H, Greiner Andreas, Paletta Jürgen R J, Fuchs-Winkelmann Susanne
机构信息
Department of Orthopedics, University of Marburg, D-35043 Marburg, Baldingerstrasse, Germany.
出版信息
ScientificWorldJournal. 2009 Feb 15;9:118-29. doi: 10.1100/tsw.2009.13.
Abstract
We developed a nanofiber scaffold by blending PLLA with collagen I, suitable for bone regeneration. Among several PLLA-COLI ratios tested, cell growth was better enhanced when blends with a ratio of PLLA-COLI 4:1 were used. Here, growth as well as osteoblast differentiation of hMSC was improved when compared to PLLA nanofibers alone. Therefore, blending is a suitable tool to enhance PLLA nanofibers with respect to bone tissue engineering.
摘要
我们通过将聚乳酸（PLLA）与I型胶原蛋白混合，开发出了一种适用于骨再生的纳米纤维支架。在测试的几种PLLA-COLI比例中，使用PLLA-COLI比例为4:1的混合物时，细胞生长得到了更好的促进。在此，与单独的PLLA纳米纤维相比，人骨髓间充质干细胞（hMSC）的生长以及成骨细胞分化都得到了改善。因此，混合是一种在骨组织工程方面增强PLLA纳米纤维的合适方法。
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