Schofer Markus D, Boudriot Ulrich, Leifeld Irini, Sütterlin Romina I, Rudisile Markus, Wendorff Joachim H, Greiner Andreas, Paletta Jürgen R J, Fuchs-Winkelmann Susanne
Department of Orthopedics, University of Marburg, D-35043 Marburg, Baldingerstrasse, Germany.
ScientificWorldJournal. 2009 Feb 15;9:118-29. doi: 10.1100/tsw.2009.13.
We developed a nanofiber scaffold by blending PLLA with collagen I, suitable for bone regeneration. Among several PLLA-COLI ratios tested, cell growth was better enhanced when blends with a ratio of PLLA-COLI 4:1 were used. Here, growth as well as osteoblast differentiation of hMSC was improved when compared to PLLA nanofibers alone. Therefore, blending is a suitable tool to enhance PLLA nanofibers with respect to bone tissue engineering.
我们通过将聚乳酸（PLLA）与I型胶原蛋白混合，开发出了一种适用于骨再生的纳米纤维支架。在测试的几种PLLA-COLI比例中，使用PLLA-COLI比例为4:1的混合物时，细胞生长得到了更好的促进。在此，与单独的PLLA纳米纤维相比，人骨髓间充质干细胞（hMSC）的生长以及成骨细胞分化都得到了改善。因此，混合是一种在骨组织工程方面增强PLLA纳米纤维的合适方法。
