Wong Thian-Sze, Ho Wai-Kuen, Chan Jimmy Yu-Wai, Ng Raymond Wai-Man, Wei William Ignace
Department of Surgery, Faculty of Medicine, The University of Hong Kong.
ScientificWorldJournal. 2009 Feb 15;9:130-2. doi: 10.1100/tsw.2009.12.
Human microRNA 184 (miR-184) is overexpressed in squamous cell carcinoma (SCC) of the tongue. In vitro inhibition of miR-184 levels could induce apoptosis and hinder proliferation of tongue SCC cells. Patients with tongue SCC have high plasma miR-184 levels. Plasma miR-184 is likely associated with the tumor load. Surgical removal of the primary tumor reduced plasma miR-184 levels significantly. The data suggested that miR-184 is linked to the pathogenesis of tongue SCC. Further studies are warranted to evaluate the use of microRNA-based serological markers in monitoring tongue SCC.
人类微小RNA 184（miR-184）在舌鳞状细胞癌（SCC）中过表达。体外抑制miR-184水平可诱导舌鳞状细胞癌细胞凋亡并阻碍其增殖。舌鳞状细胞癌患者血浆miR-184水平较高。血浆miR-184可能与肿瘤负荷有关。手术切除原发性肿瘤可显著降低血浆miR-184水平。数据表明，miR-184与舌鳞状细胞癌的发病机制有关。有必要进一步研究评估基于微小RNA的血清学标志物在监测舌鳞状细胞癌中的应用。
