Um Sang-Won, Ki Chang-Seok, Kwon O Jung, Koh Won-Jung
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Korea.
Lung. 2009 Mar-Apr;187(2):136-40. doi: 10.1007/s00408-009-9136-8. Epub 2009 Feb 14.
Human leukocyte antigen (HLA) molecules are known to play an important role in host-defense mechanisms. The aim of this study was to evaluate the association between HLA alleles and lung disease caused by nontuberculous mycobacteria (NTM) in Korean patients.
Seventy-eight patients with NTM lung disease (48 patients with Mycobacterium avium-intracellulare complex [MAC] infection and 30 patients with Mycobacterium abscessus infection) were included in the study. HLA-A, -B, and -DRB1 genotyping was performed by polymerase chain reaction using sequence-specific primers. Data from 485 healthy Korean individuals were used as a control.
When compared to controls, patients with NTM lung disease showed an increased frequency of DRB111 (OR = 1.91, 95% confidence interval [CI] = 1.01-3.64, p = 0.045, corrected p [pC] > 0.05). In the subgroup analysis, patients with MAC lung disease had an increased frequency of B46 (OR = 2.23, 95% CI = 1.05-4.73, p = 0.044, pC > 0.05).
Our data suggest that in a Korean population, patients with NTM lung disease and healthy subjects differ in the frequencies of some HLA alleles. However, when considering corrected p values, our findings are inconclusive.
已知人类白细胞抗原（HLA）分子在宿主防御机制中发挥重要作用。本研究的目的是评估韩国患者中HLA等位基因与非结核分枝杆菌（NTM）所致肺部疾病之间的关联。
本研究纳入了78例NTM肺病患者（48例鸟分枝杆菌复合群[MAC]感染患者和30例脓肿分枝杆菌感染患者）。采用序列特异性引物通过聚合酶链反应进行HLA - A、- B和 - DRB1基因分型。将485名健康韩国人的数据用作对照。
与对照组相比，NTM肺病患者中DRB111的频率增加（比值比[OR]=1.91，95%置信区间[CI]=1.01 - 3.64，p = 0.045，校正p值[pC]>0.05）。在亚组分析中，MAC肺病患者中B46的频率增加（OR = 2.23，95% CI = 1.05 - 4.73，p = 0.044，pC>0.05）。
我们的数据表明，在韩国人群中，NTM肺病患者和健康受试者在某些HLA等位基因频率上存在差异。然而，考虑校正p值时，我们的发现尚无定论。
