北美艾滋病患者中DRB1*1501与播散性鸟分枝杆菌复合体感染的关联。

Association of DRB1*1501 with disseminated Mycobacterium avium complex infection in North American AIDS patients.

作者信息

LeBlanc S B, Naik E G, Jacobson L, Kaslow R A

机构信息

Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 35294-0022, USA.

出版信息

Tissue Antigens. 2000 Jan;55(1):17-23. doi: 10.1034/j.1399-0039.2000.550103.x.

DOI:10.1034/j.1399-0039.2000.550103.x

PMID:10703603

Abstract

The HLA class II allele, DR2 (DRB11501), has been repeatedly found to be associated with development of tuberculosis and leprosy. We searched for associations of these and other class II alleles with disseminated Mycobacterium avium complex infection (DMAC) in North American Caucasian homosexual AIDS patients. Molecular typing for HLA-DRB1 and -DQB1 alleles in 176 cases of DMAC and 176 matched controls showed an association of accelerated onset of disease with DRB11501 (and the closely linked DQB10602) that was stronger upon adjustment for the degree and duration of CD4+ cell deficiency (P=0.04) and in multivariate analysis (P=0.02) than in unadjusted analysis. A similar trend was seen with DRB10701, and no other allele showed a relationship of similar magnitude. M. avium complex organisms may more effectively evade host defenses in individuals carrying an HLA polymorphism identical to that associated with M. tuberculosis and M. leprae.

摘要

人类白细胞抗原II类等位基因DR2（DRB11501）已被多次发现与结核病和麻风病的发生有关。我们在北美白种人同性恋艾滋病患者中寻找这些及其他II类等位基因与播散性鸟分枝杆菌复合群感染（DMAC）的关联。对176例DMAC患者和176例匹配对照进行HLA-DRB1和-DQB1等位基因的分子分型，结果显示疾病的加速发作与DRB11501（以及紧密连锁的DQB10602）相关，在对CD4+细胞缺乏的程度和持续时间进行校正后（P=0.04）以及在多变量分析中（P=0.02），这种相关性比未校正分析时更强。DRB10701也观察到类似趋势，没有其他等位基因显示出类似程度的关系。携带与结核分枝杆菌和麻风分枝杆菌相关的相同HLA多态性的个体中，鸟分枝杆菌复合群生物体可能更有效地逃避宿主防御。