Arentsen Harm C, Hendricksen Kees, Oosterwijk Egbert, Witjes J Alfred
Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands.
World J Urol. 2009 Jun;27(3):313-7. doi: 10.1007/s00345-009-0381-5. Epub 2009 Feb 15.
Bladder cancer is a major public health problem. Currently available therapeutic options seem to be unable to prevent bladder cancer recurrence and progression. To enable preclinical testing of new intravesical therapeutic agents, a suitable bladder tumor model that resembles human disease is highly desirable. The aim of this topic paper was to discuss the problems associated with current in vivo animal bladder tumor models, focusing on the orthotopic syngeneic rat bladder tumor model. In the second part of the paper the development of a potential new orthotopic rat bladder tumor model is described.
膀胱癌是一个重大的公共卫生问题。目前可用的治疗方案似乎无法预防膀胱癌的复发和进展。为了能够对新的膀胱内治疗药物进行临床前测试，非常需要一种类似于人类疾病的合适膀胱肿瘤模型。本专题论文的目的是讨论当前体内动物膀胱肿瘤模型相关的问题，重点是原位同基因大鼠膀胱肿瘤模型。在论文的第二部分，描述了一种潜在的新的原位大鼠膀胱肿瘤模型的开发情况。
