Kennedy Andrew S, Nutting Charles, Jakobs Tobias, Cianni Roberto, Notarianni Ermanno, Ofer Amos, Beny Alex, Dezarn William A
Wake Radiology Oncology, Cary, North Carolina 27518, USA.
Cancer Invest. 2009 Jul;27(6):682-90. doi: 10.1080/07357900802620893.
Ocular melanoma (OM) metastasizes to the liver and is rapidly fatal despite aggressive therapy. Yttrium-90 microspheres (radioembolization) delivered via the hepatic artery is an established and effective approach for primary and metastatic hepatic tumors, although (90)Y use in OM has not been reported previously.
A retrospective review was performed for all patients with OM who received radioembolization at 5 centers.
11 patients received 12 treatments with a median activity of 1.55 GBq delivered per treatment. Toxicity was minimal, with PET/CT at 3 months posttreatment showing a response in all patients; 1 patient had a complete response.
Radioembolization can control hepatic metastases of OM with very few side effects.
眼部黑色素瘤（OM）会转移至肝脏，尽管采取积极治疗，病情仍会迅速恶化至致命。经肝动脉注入钇-90微球（放射性栓塞）是治疗原发性和转移性肝肿瘤的一种成熟且有效的方法，不过此前尚未有关于钇-90用于眼部黑色素瘤治疗的报道。
对5个中心接受放射性栓塞治疗的所有眼部黑色素瘤患者进行回顾性研究。
11例患者接受了12次治疗，每次治疗的中位活度为1.55GBq。毒性极小，治疗后3个月的PET/CT显示所有患者均有反应；1例患者完全缓解。
放射性栓塞可控制眼部黑色素瘤的肝转移，且副作用极少。
