Teo Yong-Chua, Chua Guan-Leong
Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore.
Chemistry. 2009;15(13):3072-5. doi: 10.1002/chem.200802483.
Cobalt 'n' cross-coupling! A facile and practical strategy catalyzed by CoCl(2)6 H(2)O has been developed for the N-arylation of nitrogen nucleophiles with substituted aryl halides in water. The protocol is very simple and requires only mild conditions. A variety of nitrogen nucleophiles, including pyrazole, indole, and 7-azaindole, undergo catalysis to afford N-arylated products in moderate to good yields (up to 86 %; see scheme).
钴与交叉偶联！已开发出一种由六水合氯化钴催化的简便实用策略，用于在水中使含氮亲核试剂与取代芳基卤化物进行N - 芳基化反应。该方案非常简单，仅需温和的条件。多种含氮亲核试剂，包括吡唑、吲哚和7 - 氮杂吲哚，均可发生催化反应，以中等至良好的产率（高达86%；见反应式）得到N - 芳基化产物。
