组蛋白精氨酸甲基化：它们在染色质动态变化和转录调控中的作用。
Histone arginine methylations: their roles in chromatin dynamics and transcriptional regulation.
作者信息
Litt Michael, Qiu Yi, Huang Suming
机构信息
Medical Education Center, Ball State University, Muncie, IN 47302, USA.
出版信息
Biosci Rep. 2009 Apr;29(2):131-41. doi: 10.1042/BSR20080176.
Abstract
PRMTs (protein arginine N-methyltransferases) specifically modify the arginine residues of key cellular and nuclear proteins as well as histone substrates. Like lysine methylation, transcriptional repression or activation is dependent upon the site and type of arginine methylation on histone tails. Recent discoveries imply that histone arginine methylation is an important modulator of dynamic chromatin regulation and transcriptional controls. However, under the shadow of lysine methylation, the roles of histone arginine methylation have been under-explored. The present review focuses on the roles of histone arginine methylation in the regulation of gene expression, and the interplays between histone arginine methylation, histone acetylation, lysine methylation and chromatin remodelling factors. In addition, we discuss the dynamic regulation of arginine methylation by arginine demethylases, and how dysregulation of PRMTs and their activities are linked to human diseases such as cancer.
摘要
蛋白质精氨酸N-甲基转移酶（PRMTs）特异性修饰关键细胞和核蛋白以及组蛋白底物的精氨酸残基。与赖氨酸甲基化一样，转录抑制或激活取决于组蛋白尾部精氨酸甲基化的位点和类型。最近的发现表明，组蛋白精氨酸甲基化是动态染色质调控和转录控制的重要调节因子。然而，在赖氨酸甲基化的影响下，组蛋白精氨酸甲基化的作用尚未得到充分研究。本综述重点关注组蛋白精氨酸甲基化在基因表达调控中的作用，以及组蛋白精氨酸甲基化、组蛋白乙酰化、赖氨酸甲基化和染色质重塑因子之间的相互作用。此外，我们还讨论了精氨酸去甲基酶对精氨酸甲基化的动态调控，以及PRMTs及其活性的失调如何与癌症等人类疾病相关联。
相似文献
1
Histone arginine methylations: their roles in chromatin dynamics and transcriptional regulation.组蛋白精氨酸甲基化：它们在染色质动态变化和转录调控中的作用。
Biosci Rep. 2009 Apr;29(2):131-41. doi: 10.1042/BSR20080176.
2
Interplay between chromatin remodelers and protein arginine methyltransferases.染色质重塑因子与蛋白质精氨酸甲基转移酶之间的相互作用。
J Cell Physiol. 2007 Nov;213(2):306-15. doi: 10.1002/jcp.21180.
3
Histone arginine methylation and its dynamic regulation.组蛋白精氨酸甲基化及其动态调控。
Front Biosci. 2006 Jan 1;11:344-55. doi: 10.2741/1802.
4
[Advances in histone methyltransferases and histone demethylases].[组蛋白甲基转移酶和组蛋白去甲基化酶的研究进展]
Ai Zheng. 2008 Oct;27(10):1018-25.
5
A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin.CARM1 介导的组蛋白 H3 精氨酸甲基化在通过从染色质释放核心抑制物来保护组蛋白乙酰化中的作用。
PLoS One. 2012;7(6):e34692. doi: 10.1371/journal.pone.0034692. Epub 2012 Jun 18.
6
The macromolecular complexes of histones affect protein arginine methyltransferase activities.组蛋白的大分子复合物会影响蛋白质精氨酸甲基转移酶的活性。
J Biol Chem. 2021 Oct;297(4):101123. doi: 10.1016/j.jbc.2021.101123. Epub 2021 Sep 6.
7
Crosstalk between CARM1 methylation and CBP acetylation on histone H3.组蛋白H3上CARM1甲基化与CBP乙酰化之间的相互作用
Curr Biol. 2002 Dec 23;12(24):2090-7. doi: 10.1016/s0960-9822(02)01387-8.
8
Histone arginine methylation.组蛋白精氨酸甲基化。
FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.
9
Intricate Effects of α-Amino and Lysine Modifications on Arginine Methylation of the N-Terminal Tail of Histone H4.α-氨基和赖氨酸修饰对组蛋白H4 N端尾巴精氨酸甲基化的复杂影响
Biochemistry. 2017 Jul 18;56(28):3539-3548. doi: 10.1021/acs.biochem.7b00450. Epub 2017 Jul 7.
10
Assaying epigenome functions of PRMTs and their substrates.检测 PRMTs 及其底物的表观基因组功能。
Methods. 2020 Mar 15;175:53-65. doi: 10.1016/j.ymeth.2019.09.014. Epub 2019 Sep 19.
引用本文的文献
1
From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health.从谱系到长寿：表观遗传学对后代健康影响的关键因素实用指南
Curr Issues Mol Biol. 2025 Apr 30;47(5):323. doi: 10.3390/cimb47050323.
2
LncRNA-Histone Modification Crosstalk: Orchestrating Cancer Pathobiology.长链非编码RNA与组蛋白修饰的相互作用：调控癌症病理生物学
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul 11. doi: 10.1007/s00210-025-04402-6.
3
Management of T-cell malignancies: Bench-to-bedside targeting of epigenetic biology.T细胞恶性肿瘤的管理：从 bench 到床边的表观遗传生物学靶向治疗
CA Cancer J Clin. 2025 Jul-Aug;75(4):282-307. doi: 10.3322/caac.70001. Epub 2025 Apr 15.
4
Epigenetic regulation in muscle-invasive urothelial carcinoma of the bladder in the dog, a translational model of human cancer.犬膀胱肌层浸润性尿路上皮癌中的表观遗传调控，一种人类癌症的转化模型。
Vet Oncol. 2024;1. doi: 10.1186/s44356-024-00011-2. Epub 2024 Nov 20.
5
Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury.精氨酸甲基转移酶PRMT1通过EGR1/GLS2轴在脓毒症相关急性肺损伤中促进铁死亡。
Commun Biol. 2025 Feb 3;8(1):159. doi: 10.1038/s42003-025-07531-z.
6
'Nomadic' Hematopoietic Stem Cells Navigate the Embryonic Landscape.“游牧”造血干细胞在胚胎环境中导航。
Stem Cell Rev Rep. 2025 Apr;21(3):605-628. doi: 10.1007/s12015-025-10843-6. Epub 2025 Jan 9.
7
Epigenetic Explorations of Neurological Disorders, the Identification Methods, and Therapeutic Avenues.神经紊乱的表观遗传学探索、鉴定方法和治疗途径。
Int J Mol Sci. 2024 Oct 30;25(21):11658. doi: 10.3390/ijms252111658.
8
Role of PRMT1 and PRMT5 in Breast Cancer.PRMT1 和 PRMT5 在乳腺癌中的作用。
Int J Mol Sci. 2024 Aug 14;25(16):8854. doi: 10.3390/ijms25168854.
9
Contribution of Electrostatic CH-π Interactions to Recognition of Histone Asymmetric Dimethylarginine by the SPIN1 Triple Tudor Domain.静电 CH-π 相互作用对 SPIN1 三串联 Tudor 结构域识别组蛋白非对称二甲基精氨酸的贡献。
J Am Chem Soc. 2024 Jul 31;146(30):20678-20684. doi: 10.1021/jacs.4c03463. Epub 2024 Jul 18.
10
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos.LincGET 引导的核小体易位酶 1（CARM1）可变剪接通过形成核旁体偏置哺乳动物早期胚胎中的第一个细胞命运。
Nat Struct Mol Biol. 2024 Sep;31(9):1341-1354. doi: 10.1038/s41594-024-01292-9. Epub 2024 Apr 24.
本文引用的文献
1
Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.蛋白质精氨酸甲基转移酶5抑制白血病和淋巴瘤细胞中肿瘤抑制因子RB家族的转录。
Mol Cell Biol. 2008 Oct;28(20):6262-77. doi: 10.1128/MCB.00923-08. Epub 2008 Aug 11.
2
Regulation of estrogen rapid signaling through arginine methylation by PRMT1.PRMT1通过精氨酸甲基化对雌激素快速信号传导的调控。
Mol Cell. 2008 Jul 25;31(2):212-21. doi: 10.1016/j.molcel.2008.05.025.
3
The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation.蛋白质精氨酸甲基转移酶CARM1和PRMT1在基因调控中协同作用。
Nucleic Acids Res. 2008 Jun;36(10):3202-13. doi: 10.1093/nar/gkn166. Epub 2008 Apr 15.
4
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.组蛋白结合蛋白COPR5是蛋白质精氨酸甲基转移酶PRMT5核功能所必需的。
EMBO Rep. 2008 May;9(5):452-8. doi: 10.1038/embor.2008.45. Epub 2008 Apr 11.
5
Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.PRMT1对RUNX1的甲基化作用消除了SIN3A的结合，并增强了其转录活性。
Genes Dev. 2008 Mar 1;22(5):640-53. doi: 10.1101/gad.1632608.
6
PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation.蛋白精氨酸甲基转移酶6介导的组蛋白H3中R2位点的甲基化可拮抗组蛋白H3第4位赖氨酸的三甲基化。
Genes Dev. 2007 Dec 15;21(24):3369-80. doi: 10.1101/gad.447007.
7
Covalent modifications of histones during development and disease pathogenesis.发育和疾病发病机制过程中组蛋白的共价修饰。
Nat Struct Mol Biol. 2007 Nov;14(11):1008-16. doi: 10.1038/nsmb1337. Epub 2007 Nov 5.
8
JMJD6 is a histone arginine demethylase.JMJD6是一种组蛋白精氨酸去甲基化酶。
Science. 2007 Oct 19;318(5849):444-7. doi: 10.1126/science.1145801.
9
Histone lysine demethylases: emerging roles in development, physiology and disease.组蛋白赖氨酸去甲基化酶：在发育、生理和疾病中的新作用
Nat Rev Genet. 2007 Nov;8(11):829-33. doi: 10.1038/nrg2218.
10
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation.组蛋白H3第2位精氨酸的甲基化调控H3K4三甲基化的沉积。
Nature. 2007 Oct 18;449(7164):928-32. doi: 10.1038/nature06160. Epub 2007 Sep 26.
Zotero 插件