Zakarya Razia
School of Life Sciences, University of Technology Sydney, Sydney 2007, Australia.
Epigenetics of Chronic Disease Group, Woolcock Institute of Medical Research, Macquarie University, Sydney 2113, Australia.
Curr Issues Mol Biol. 2025 Apr 30;47(5):323. doi: 10.3390/cimb47050323.
Epidemiological evidence firmly supports the rationale that chronic diseases demonstrate a heritability component. Notwithstanding recent advances in genomic technologies, in a significant proportion of heritable diseases, a candidate gene of interest that explains the entire picture of heritability remains to be identified. Further epidemiological evidence points to environmental risk factors contributing to chronic disease prevalence and severity. The Developmental Origins of Health and Disease hypothesis points to epigenetics as the mechanism modulating gene-environment interactions to elicit disease. Yet the primary effector of epigenetic inheritance remains to be elucidated. This review focuses on key contributors to mammalian development and the epigenetic changes measured therein, to draw attention towards potential molecular candidates underpinning chronic disease heritability.
流行病学证据有力地支持了慢性病具有遗传成分这一理论依据。尽管基因组技术最近取得了进展，但在很大一部分遗传性疾病中，仍有待确定一个能解释遗传全貌的目标候选基因。更多的流行病学证据表明环境风险因素会导致慢性病的流行和严重程度。健康与疾病的发育起源假说指出，表观遗传学是调节基因与环境相互作用以引发疾病的机制。然而，表观遗传继承的主要效应器仍有待阐明。本综述聚焦于哺乳动物发育的关键因素以及其中所测量到的表观遗传变化，以引起人们对支撑慢性病遗传性的潜在分子候选物的关注。
