阴茎鳞状细胞癌分级和分期的观察者间差异与临床结局的关系。
Interobserver variation in grading and staging of squamous cell carcinoma of the penis in relation to the clinical outcome.
作者信息
Naumann Carsten M, Alkatout Ibrahim, Hamann Moritz F, Al-Najar Amr, Hegele Axel, Korda Joanna B, Bolenz Christian, Klöppel Günter, Jünemann Klaus-Peter, van der Horst Christof
机构信息
Department of Urology and Paediatric Urology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str. 7, D-24105 Kiel, Germany.
出版信息
BJU Int. 2009 Jun;103(12):1660-5. doi: 10.1111/j.1464-410X.2009.08362.x. Epub 2009 Feb 9.
OBJECTIVE
To examine interobserver variations in assessing grade and stage of penile squamous cell carcinoma (SCC).
PATIENTS AND METHODS
We retrospectively reviewed the pathological features and clinical outcome in 75 patients with SCC of the penis, who were treated in participating urological centres between 1996 and 2005; the assessments of the local pathologists and the review pathologists were compared.
RESULTS
There was conformity in tumour grade in 67% and the assessment of tumour stage conformed in 84%; the combination assessment of both grade and stage conformed in 56%.
CONCLUSION
Accurate histological subtyping by the surgical pathologist demands standardized guidelines, in particular for histological grading, which is crucial for clinical treatment, but shows significant interobserver variation.
目的
研究阴茎鳞状细胞癌（SCC）分级和分期评估中观察者间的差异。
患者与方法
我们回顾性分析了1996年至2005年间在参与研究的泌尿外科中心接受治疗的75例阴茎SCC患者的病理特征和临床结果；比较了当地病理学家和复审病理学家的评估结果。
结果
肿瘤分级的符合率为67%，肿瘤分期的评估符合率为84%；分级和分期的联合评估符合率为56%。
结论
手术病理学家进行准确的组织学亚型分类需要标准化指南，特别是对于组织学分级，这对临床治疗至关重要，但观察者间存在显著差异。
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