Harboe E, Beyer M K, Greve O J, Gøransson L G, Tjensvoll A B, Kvaløy J T, Omdal R
Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.
Eur J Neurol. 2009 May;16(5):576-81. doi: 10.1111/j.1468-1331.2009.02537.x. Epub 2009 Feb 11.
It is frequently thought that cerebral white matter hyperintensities (WMHs) on T-2 weighted MRI scans are increased in patients with autoimmune diseases. An increased frequency of WHMs has been described in primary Sjögren's syndrome (PSS), but no controlled studies exist. The aim of this study was therefore to compare WMHs in PSS patients and healthy subjects applying the new European-American criteria for PSS.
Cross-sectional controlled study of 68 unselected PSS patients and 68 healthy subjects was carried out. WMHs were rated using Scheltens method.
There were no differences in total or any regional WMH scores between PSS patients and healthy subjects.
Patients with PSS do not have increased WMH load or distribution when compared with healthy subjects.
人们常常认为，自身免疫性疾病患者T2加权磁共振成像扫描显示的脑白质高信号（WMHs）会增多。原发性干燥综合征（PSS）患者中WMHs的发生频率有所增加，但尚无对照研究。因此，本研究旨在采用新的欧美PSS标准，比较PSS患者与健康受试者的WMHs情况。
对68例未经挑选的PSS患者和68例健康受试者进行横断面对照研究。采用斯海尔滕斯方法对WMHs进行评分。
PSS患者与健康受试者在总的或任何区域的WMH评分上均无差异。
与健康受试者相比，PSS患者的WMH负荷或分布并未增加。
