Baud P, Perroud N, Courtet P, Jaussent I, Relecom C, Jollant F, Malafosse A
Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland.
Genes Brain Behav. 2009 Feb;8(1):97-100. doi: 10.1111/j.1601-183X.2008.00451.x.
A genetic association between the tryptophan hydroxylase gene (TPH)-1 A218C polymorphism and suicidal behaviour is supported by numerous case-control studies as well as recent meta-analyses. Some data suggest that this polymorphism could also influence individual differences in anger-related personality traits, a phenotype partially under genetic control and known to increase the risk of suicide ideation and attempt. The aim of the present study was to investigate whether the TPH-1 A218C polymorphism affected anger-related personality traits in suicide attempters (n = 544). We hypothesized that suicide attempters carrying the AA genotype would display different scores on a scale measuring anger-related traits compared with suicide attempters carrying the CC genotype. Indeed, the dimension of Anger Control was significantly affected by the TPH-1 A218C polymorphism: suicide attempters carrying the AA genotype scored significantly lower on the Anger Control subscale than suicide attempters carrying the AC and CC genotypes. This polymorphism did not display any influence on the other State-Trait Anger Expression Inventory subscales. This result confirms our working hypothesis and suggests that the TPH-1 genotype could confer a vulnerability to suicidal behaviour through a reduced capacity to control anger, which in turn may represent a common psychopathological and behavioural pathway to suicidal behaviour in an important subgroup of clinical subjects.
色氨酸羟化酶基因（TPH）-1 A218C多态性与自杀行为之间的遗传关联得到了众多病例对照研究以及近期荟萃分析的支持。一些数据表明，这种多态性也可能影响与愤怒相关的人格特质的个体差异，这种表型部分受遗传控制，并且已知会增加自杀意念和自杀未遂的风险。本研究的目的是调查TPH-1 A218C多态性是否会影响自杀未遂者（n = 544）与愤怒相关的人格特质。我们假设，与携带CC基因型的自杀未遂者相比，携带AA基因型的自杀未遂者在测量与愤怒相关特质的量表上会表现出不同的分数。确实，愤怒控制维度受到TPH-1 A218C多态性的显著影响：携带AA基因型的自杀未遂者在愤怒控制子量表上的得分显著低于携带AC和CC基因型的自杀未遂者。这种多态性对状态-特质愤怒表达量表的其他子量表没有任何影响。这一结果证实了我们的工作假设，并表明TPH-1基因型可能通过降低控制愤怒的能力使人易患自杀行为，这反过来可能代表了临床受试者一个重要亚组中自杀行为常见的心理病理和行为途径。
