Genis-Mendoza Alma Delia, Hernández-Díaz Yazmín, González-Castro Thelma Beatriz, Tovilla-Zárate Carlos Alfonso, Castillo-Avila Rosa Giannina, López-Narváez María Lilia, Ramos-Méndez Miguel Ángel, Nicolini Humberto
Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México, Mexico.
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Mexico.
Front Psychiatry. 2022 Jul 19;13:932135. doi: 10.3389/fpsyt.2022.932135. eCollection 2022.
We aimed to examine the association of polymorphisms with the risk of suicide behavior (SB).
Systematic review and meta-analysis.
All relevant studies that evaluated the association between the A218C (rs1800532), A779C (rs1799913) and A6526G (rs4537731) polymorphisms and the susceptibility to SB published up to September 2021 were identified through a comprehensive systematic search in PubMed, Scopus, EBSCO and Science Direct electronic databases. The association between gene polymorphisms and SB was evaluated using inherence models by odds ratio (OR) and 95% confidence interval (CI). Subgroup analyses, heterogeneity analyses, and publication bias were also tested in this meta-analysis.
The meta-analysis for A218C revealed an increased risk of SB in the dominant model (OR = 1.11, 95%CI 1.01-1.22). We also observed a positive association in the allelic (OR = 1.13, 95%CI 1.05-1.21), homozygous (OR = 1.22, 95%CI 1.06-1.40), heterozygous (OR = 1.21, 95%CI 1.08-1.37) and dominant (OR = 1.21, 95%CI 1.09-1.34) inherence models with the suicide attempt. Additionally, in the heterozygous (OR = 0.84, 95%CI 0.73-0.97) and dominant (OR = 0.79, 95%CI 0.68-0.91) inherence models we detected an association with completed suicide. Based on ethnicity, an association of SB in the European population also was observed (OR = 1.29, 95%CI 1.12-1.51). However, for both A779C and A6526G polymorphisms we did not find evidence of an association with SB.
This meta-analysis suggests that the A218C polymorphism of gene could be a possible risk factor of SB. Future large-scale studies are required to analyze the molecular mechanisms by which affect the susceptibility of developing suicide behavior.
我们旨在研究基因多态性与自杀行为（SB）风险之间的关联。
系统评价与荟萃分析。
通过对PubMed、Scopus、EBSCO和Science Direct电子数据库进行全面系统检索，确定了截至2021年9月发表的所有评估A218C（rs1800532）、A779C（rs1799913）和A6526G（rs4537731）基因多态性与SB易感性之间关联的相关研究。使用比值比（OR）和95%置信区间（CI）的遗传模型评估基因多态性与SB之间的关联。在这项荟萃分析中还进行了亚组分析、异质性分析和发表偏倚检验。
A218C的荟萃分析显示，在显性模型中SB风险增加（OR = 1.11，95%CI 1.01 - 1.22）。我们还在等位基因（OR = 1.13，95%CI 1.05 - 1.21）、纯合子（OR = 1.22，95%CI 1.06 - 1.40）、杂合子（OR = 1.21，95%CI 1.08 - 1.37）和显性（OR = 1.21，95%CI 1.09 - 1.34）遗传模型中观察到与自杀未遂的正相关。此外，在杂合子（OR = 0.84，95%CI 0.73 - 0.97）和显性（OR = 0.79，95%CI 0.68 - 0.91）遗传模型中，我们检测到与自杀死亡的关联。基于种族，在欧洲人群中也观察到SB的关联（OR = 1.29，95%CI 1.12 - 1.51）。然而，对于A779C和A6526G多态性，我们没有发现与SB相关的证据。
这项荟萃分析表明，该基因的A218C多态性可能是SB的一个潜在风险因素。未来需要进行大规模研究来分析影响自杀行为易感性的分子机制。
