Bommineni Y R, Dick E J, Hubbard G B
Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX 76227-5301, USA.
J Med Primatol. 2009 Jun;38(3):199-203. doi: 10.1111/j.1600-0684.2009.00339.x. Epub 2009 Feb 10.
Gastrointestinal stromal tumors (GISTs) are believed to originate from the intestinal pacemaker cells (interstitial cells of Cajal) or their progenitor cells. Spontaneous tumors have been reported in dogs, horses, rhesus, and a chimpanzee and they have been produced experimentally in mice and rats. GISTs represent a diagnostic challenge because they cannot be differentiated from non-lymphoid mesenchymal tumors without using human c-kit (CD117) immunohistochemistry.
Three neoplasms were incidental findings at necropsy in the stomachs of a baboon and a spider monkey and in the rectum of a chimpanzee.
The GISTs were initially diagnosed grossly and histologically with hematoxylin and eosin as leiomyomas. Immunohistochemical analysis revealed that all three were c-kit (CD117) positive.
These are the first reports of GISTs in the baboon and spider monkey and the second in a chimpanzee. The occurrence of GISTs in non-human primates may provide a unique opportunity to study these tumors.
胃肠道间质瘤（GISTs）被认为起源于肠道起搏细胞（Cajal间质细胞）或其祖细胞。自发性肿瘤已在犬、马、恒河猴和黑猩猩中被报道，并且已在小鼠和大鼠中通过实验诱导产生。GISTs是一个诊断难题，因为在不使用人c-kit（CD117）免疫组织化学的情况下，它们无法与非淋巴间叶肿瘤相区分。
三只肿瘤是在一只狒狒、一只蜘蛛猴的胃以及一只黑猩猩的直肠尸检时偶然发现的。
这些GISTs最初通过苏木精和伊红染色在大体和组织学上被诊断为平滑肌瘤。免疫组织化学分析显示，所有三只肿瘤均为c-kit（CD117）阳性。
这些是关于狒狒和蜘蛛猴中GISTs的首次报道，也是黑猩猩中的第二次报道。非人类灵长类动物中GISTs的发生可能为研究这些肿瘤提供独特的机会。
