一只黑猩猩（黑猩猩属）胃食管交界处的自发性平滑肌瘤。
Spontaneous leiomyomas of the gastroesophageal junction in a chimpanzee (Pan troglodytes).
作者信息
Gumber Sanjeev, Stovall Melissa I, Breding Eileen, Crane Maria M
机构信息
Division of Pathology, Yerkes National Primate Research Center, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Division of Veterinary Medicine, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
出版信息
Comp Med. 2014 Jun;64(3):230-3.
A 49-y-old, female chimpanzee presented with a history of cardiac failure. Postmortem examination revealed lesions consistent with congestive heart failure and 2 incidental, round, firm, pale-tan intramural nodules (diameter, 2 cm) in the stomach at the gastroesophageal junction (GEJ). Histologically, the GEJ nodules were diagnosed as benign spindle-cell tumors. Immunohistochemical evaluation revealed neoplastic cells diffusely labeled with α-smooth muscle actin and vimentin, multifocally labeled for desmin, and were negative for c-kit (CD117). Electron microscopy revealed intracytoplasmic bundles of myofilaments with dense bodies, basal lamina, and few pinocytic vesicles in the neoplastic cells. According to these findings, leiomyomas of the GEJ were diagnosed. Gastrointestinal stromal tumors have been documented to occur in chimpanzees, but there are no reports of GEJ leiomyomas. To our knowledge, this report is the first description of spontaneous leiomyomas of the GEJ in a chimpanzee.
一只49岁的雌性黑猩猩出现心力衰竭病史。尸检发现病变符合充血性心力衰竭，且在胃食管交界处（GEJ）有2个偶然发现的圆形、坚实、淡黄褐色的壁内结节（直径2厘米）。组织学上，GEJ结节被诊断为良性梭形细胞瘤。免疫组化评估显示肿瘤细胞弥漫性标记有α-平滑肌肌动蛋白和波形蛋白，局灶性标记有结蛋白，且c-kit（CD117）为阴性。电子显微镜显示肿瘤细胞内有含致密体的肌丝束、基膜和少量吞饮小泡。根据这些发现，诊断为GEJ平滑肌瘤。胃肠道间质瘤已被记录在黑猩猩中发生，但尚无GEJ平滑肌瘤的报告。据我们所知，本报告是对黑猩猩中GEJ自发性平滑肌瘤的首次描述。
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