Clin Implant Dent Relat Res. 2009 Oct;11 Suppl 1:e7-13. doi: 10.1111/j.1708-8208.2008.00141.x. Epub 2009 Feb 13.
The aim of this preliminary study was to evaluate histologically a nanocrystalline hydroxyapatite silica gel in maxillary sinus floor grafting in severely resorbed maxillae.
A total of 16 consecutive patients scheduled for sinus lift were recruited during this study. Patients were randomly divided in two groups, eight patients each. In both groups, preoperative residual bone level ranged between 1 and 3 mm (mean value of 2.03 mm). No membrane was used to occlude the buccal window. Second surgery was carried out after a healing period of 3 months in Group 1 and 6 months in Group 2. Using a trephine bur, one bone specimen was harvested from each augmented sinus and underwent histological and histomorphometric analysis.
Histological analysis showed significant new bone formation and remodeling of the grafted material. In the cores obtained at 6 months, regenerated bone, residual NanoBone, and bone marrow occupied respectively 48 +/- 4.63%, 28 +/- 5.33%, and 24 +/- 7.23% of the grafted volume. In the specimens taken 3 months after grafting, mean new bone was 8 +/- 3.34%, mean NanoBone was 45 +/- 5.10%, and mean bone marrow was 47 +/- 6.81% of the bioptical volume.
Within the limits of this preliminary prospective study, it was concluded that grafting of maxillary sinus using nanostructured hydroxyapatite silica gel as only bone filler is a reliable procedure also in critical anatomic conditions and after early healing period.
本初步研究旨在评估纳米晶羟基磷灰石硅胶在严重吸收上颌窦底骨移植中的组织学表现。
本研究共纳入 16 例连续接受鼻窦提升术的患者。将患者随机分为两组，每组 8 例。两组患者术前残留骨高度均在 1 至 3 毫米之间（平均值为 2.03 毫米）。均未使用膜来封闭颊侧窗口。第 1 组在术后 3 个月，第 2 组在术后 6 个月进行第 2 次手术。使用环钻从每个增强的窦内采集一个骨标本，并进行组织学和组织形态计量学分析。
组织学分析显示出明显的新骨形成和移植物的重塑。在 6 个月时获得的标本中，再生骨、残留的纳米骨和骨髓分别占移植体积的 48 +/- 4.63%、28 +/- 5.33%和 24 +/- 7.23%。在移植后 3 个月获得的标本中，平均新骨为 8 +/- 3.34%、平均纳米骨为 45 +/- 5.10%、平均骨髓为 47 +/- 6.81%。
在本初步前瞻性研究的范围内，可以得出结论，使用纳米结构羟基磷灰石硅胶作为唯一的骨填充物进行上颌窦移植是一种可靠的方法，即使在临界解剖条件下，也可以在早期愈合期后进行。
