University of Milan, Human Morphology and Biomedical Sciences Città Studi, Milan, Italy.
Clin Implant Dent Relat Res. 2009 Oct;11 Suppl 1:e59-68. doi: 10.1111/j.1708-8208.2009.00203.x. Epub 2009 Sep 9.
To analyze radiographic and histological outcomes of maxillary sinus floor augmentation using a calcium-sulfate based allograft containing demineralized bone matrix particles.
Fifteen maxillary sinus lift procedures with simultaneous placement of titanium implants were performed in 12 patients of both genders aged 36-71 years. Each sinus cavity was filled by the biocomposite. After 3 months of healing, all surgical sites were uncovered and bone biopsies were retrieved for undecalcified histology and histomorphometry. The ratio between the original and the grafted sinus height (GSH/OSH) was computed using a panoramic radiography taken immediately after surgery and at 3 months of healing, and the two ratios were compared by Wilcoxon signed-rank test.
By 3 months, all implants were stable without clinical and radiographic signs of infection. Significant changes in GSH/OSH during healing were seen (2.7 +/- 0.6 initially vs. 2.6 +/- 0.5 after healing; p = 0.01). Histologic findings showed newly formed bone surrounding the residual grafted particles without inflammation. At 3 months, mean regenerated bone density was 33.8 +/- 8.6%; marrow spaces amounted to 32.3 +/- 10.3%; residual graft was 33.9 +/- 9.0%. Similar histomorphometric and radiographic results were obtained independently from patient age or sex.
The analysed putty seems to be a safe and effective graft material for maxillary sinus floor augmentation by accelerating bone regeneration and thus reducing the healing time.
分析使用含有脱矿骨基质颗粒的硫酸钙基同种异体移植物进行上颌窦底提升的放射学和组织学结果。
12 名 36-71 岁的男女患者共进行了 15 例上颌窦提升术，同时植入钛种植体。每个窦腔均填充生物复合材料。愈合 3 个月后，所有手术部位均被暴露，并取出骨活检进行未脱钙组织学和组织形态计量学检查。使用手术后即刻和愈合 3 个月时拍摄的全景片计算原始窦腔高度（OSH）与移植窦腔高度（GSH）的比值（GSH/OSH），并用 Wilcoxon 符号秩检验比较这两个比值。
在 3 个月时，所有种植体均稳定，无临床和放射学感染迹象。愈合过程中 GSH/OSH 发生显著变化（初始时为 2.7 +/- 0.6，愈合后为 2.6 +/- 0.5；p = 0.01）。组织学检查显示新形成的骨环绕残留的移植颗粒，无炎症。在 3 个月时，再生骨密度的平均值为 33.8 +/- 8.6%；骨髓腔占 32.3 +/- 10.3%；残留移植物占 33.9 +/- 9.0%。无论患者年龄或性别如何，均获得相似的组织形态计量学和放射学结果。
分析的糊剂似乎是一种安全有效的上颌窦底提升移植材料，可通过加速骨再生从而减少愈合时间。
