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BioSunMS：一款基于插件的软件，用于管理患者信息以及分析质谱肽谱。

BioSunMS: a plug-in-based software for the management of patients information and the analysis of peptide profiles from mass spectrometry.

作者信息

Cao Yuan, Wang Na, Ying Xiaomin, Li Ailing, Wang Hengsha, Zhang Xuemin, Li Wuju

机构信息

Center of Computational Biology, Beijing Institute of Basic Medical Sciences, Taiping Road 27, Haidian district, Beijing 100850, PR China.

出版信息

BMC Med Inform Decis Mak. 2009 Feb 17;9:13. doi: 10.1186/1472-6947-9-13.

DOI:10.1186/1472-6947-9-13
PMID:19220920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2654546/
Abstract

BACKGROUND

With wide applications of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), statistical comparison of serum peptide profiles and management of patients information play an important role in clinical studies, such as early diagnosis, personalized medicine and biomarker discovery. However, current available software tools mainly focused on data analysis rather than providing a flexible platform for both the management of patients information and mass spectrometry (MS) data analysis.

RESULTS

Here we presented a plug-in-based software, BioSunMS, for both the management of patients information and serum peptide profiles-based statistical analysis. By integrating all functions into a user-friendly desktop application, BioSunMS provided a comprehensive solution for clinical researchers without any knowledge in programming, as well as a plug-in architecture platform with the possibility for developers to add or modify functions without need to recompile the entire application.

CONCLUSION

BioSunMS provides a plug-in-based solution for managing, analyzing, and sharing high volumes of MALDI-TOF or SELDI-TOF MS data. The software is freely distributed under GNU General Public License (GPL) and can be downloaded from http://sourceforge.net/projects/biosunms/.

摘要

背景

随着基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）和表面增强激光解吸/电离飞行时间质谱（SELDI-TOF MS）的广泛应用，血清肽谱的统计比较以及患者信息管理在临床研究中发挥着重要作用，如早期诊断、个性化医疗和生物标志物发现。然而，当前可用的软件工具主要侧重于数据分析，而非为患者信息管理和质谱（MS）数据分析提供一个灵活的平台。

结果

在此，我们展示了一款基于插件的软件BioSunMS，用于患者信息管理和基于血清肽谱的统计分析。通过将所有功能集成到一个用户友好的桌面应用程序中，BioSunMS为没有任何编程知识的临床研究人员提供了一个全面的解决方案，同时也为开发者提供了一个插件架构平台，使其能够在无需重新编译整个应用程序的情况下添加或修改功能。

结论

BioSunMS为管理、分析和共享大量MALDI-TOF或SELDI-TOF MS数据提供了基于插件的解决方案。该软件根据GNU通用公共许可证（GPL）免费分发，可从http://sourceforge.net/projects/biosunms/下载。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/0ad6e9a0b6ab/1472-6947-9-13-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/c21f19d59fee/1472-6947-9-13-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/ed7666696032/1472-6947-9-13-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/919a641481c7/1472-6947-9-13-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/e6d7b92bee6d/1472-6947-9-13-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/0ad6e9a0b6ab/1472-6947-9-13-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/c21f19d59fee/1472-6947-9-13-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/ed7666696032/1472-6947-9-13-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/919a641481c7/1472-6947-9-13-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/e6d7b92bee6d/1472-6947-9-13-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e11/2654546/0ad6e9a0b6ab/1472-6947-9-13-5.jpg

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