Straus David L, Meinelt Thomas
USDA, Agricultural Research Service, Harry K. Dupree-Stuttgart National Aquaculture Research Center, P.O. Box 1050, Stuttgart, AR 72160, USA.
Parasitol Res. 2009 Apr;104(5):1237-41. doi: 10.1007/s00436-009-1361-9. Epub 2009 Feb 17.
Peracetic acid (PAA) is an antimicrobial disinfectant used in agriculture, food processing, and medical facilities. It has recently been suggested as a means to control infestations of Ichthyophthirius multifiliis. The purpose of this study was to determine the acute toxicity of two products containing 4.5% and 40% PAA to I. multifiliis theronts from two geographically separate isolates. Theronts were exposed to concentrations of PAA in 96-well plates containing groundwater at 23 degrees C. Acute toxicity was observed over a 4-h period. No significant difference in the median lethal concentration (LC(50)) estimates was evident between the two isolates at 4 h with the 4.5% PAA product (0.146 versus 0.108 mg/l PAA), while there was a statistical difference between the 4 h LC(50) with the 40% PAA product (0.274 versus 0.158 mg/l PAA). These results suggest that PAA is toxic to I. multifiliis theronts at low concentrations and that one of the isolates was more resistant to this compound.
过氧乙酸(PAA)是一种用于农业、食品加工和医疗设施的抗菌消毒剂。最近有人提出将其作为控制多子小瓜虫感染的一种手段。本研究的目的是确定两种分别含有4.5%和40%PAA的产品对来自两个地理隔离菌株的多子小瓜虫幼虫的急性毒性。将幼虫暴露于23摄氏度含地下水的96孔板中的PAA浓度下。在4小时内观察急性毒性。使用4.5%PAA产品时,4小时时两个菌株的半数致死浓度(LC50)估计值无显著差异(分别为0.146和0.108毫克/升PAA),而使用40%PAA产品时,4小时LC50存在统计学差异(分别为0.274和0.158毫克/升PAA)。这些结果表明,PAA在低浓度下对多子小瓜虫幼虫有毒,且其中一个菌株对该化合物更具抗性。