Stull A J, Wood K V, Thyfault J P, Campbell W W
Department of Foods and Nutrition and Center on Aging and the Life Course, Purdue University, West Lafayette, IN 47907-2059, USA.
Horm Metab Res. 2009 May;41(5):381-6. doi: 10.1055/s-0028-1128140. Epub 2009 Feb 16.
Limited research with rodents and humans suggests that oral ingestion of pinitol (3- O-methyl- D- CHIRO-inositol) might positively influence glucose tolerance. This double-blinded, placebo-controlled, and cross-over study assessed the effects of acute pinitol supplementation on plasma pinitol concentration, glucose tolerance, insulin sensitivity, and activation of the skeletal muscle insulin receptor. Fifteen older, nondiabetic subjects (62+/-1 years, mean+/-SEM) completed four, 1-day trials. Subjects consumed a non-nutritive beverage with nothing (placebo) or 1,000 mg pinitol. Sixty minutes later, the subjects consumed beverages that were either energy- and carbohydrate-free (Sham) or contained 75 g glucose (OGTT). Blood samples were collected frequently over the 240-min testing period. For the OGTT trials only, vastus lateralis samples were obtained before the placebo and pinitol supplementation and 60 min after consuming the 75 g glucose beverage. Plasma pinitol concentration increased and was maintained for 240 min. Pinitol did not influence the fasting state and 180-min area under the curves for plasma glucose and insulin during the Sham and OGTT trials or hepatic (placebo 0.83+/-0.08; pinitol 0.80+/-0.08) and whole-body (placebo 6.10+/-0.54; pinitol 6.22+/-0.52) insulin sensitivities. Activation of the muscle insulin receptor was increased by 140% with glucose ingestion (Pre 0.62+/-0.12; Post 1.49+/-0.35), but pinitol did not influence this response. These results show that the pinitol supplement was quickly absorbed, but did not acutely influence indices of whole-body glucose tolerance and insulin sensitivity, or the activation of the skeletal muscle insulin receptor in older, nondiabetic humans.
对啮齿动物和人类进行的有限研究表明，口服松醇（3 - O - 甲基 - D - 手性肌醇）可能对葡萄糖耐量产生积极影响。这项双盲、安慰剂对照的交叉研究评估了急性补充松醇对血浆松醇浓度、葡萄糖耐量、胰岛素敏感性以及骨骼肌胰岛素受体激活的影响。15名年龄较大的非糖尿病受试者（62±1岁，平均值±标准误）完成了四项为期1天的试验。受试者饮用不含任何成分（安慰剂）或含有1000毫克松醇的无营养饮料。60分钟后，受试者饮用不含能量和碳水化合物的饮料（假对照）或含有75克葡萄糖的饮料（口服葡萄糖耐量试验）。在240分钟的测试期内频繁采集血样。仅在口服葡萄糖耐量试验中，于补充安慰剂和松醇之前以及饮用75克葡萄糖饮料60分钟后采集股外侧肌样本。血浆松醇浓度升高并维持240分钟。在假对照和口服葡萄糖耐量试验期间，松醇对空腹状态以及血浆葡萄糖和胰岛素曲线下180分钟面积均无影响，对肝脏（安慰剂组0.83±0.08；松醇组0.80±0.08）和全身（安慰剂组6.10±0.54；松醇组6.22±0.52）胰岛素敏感性也无影响。葡萄糖摄入使肌肉胰岛素受体激活增加了140%（摄入前0.62±0.12；摄入后1.49±0.35），但松醇对此反应无影响。这些结果表明，松醇补充剂吸收迅速，但对老年非糖尿病人类的全身葡萄糖耐量、胰岛素敏感性指标以及骨骼肌胰岛素受体激活并无急性影响。
