Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain.
Food Chem. 2013 Nov 15;141(2):1267-72. doi: 10.1016/j.foodchem.2013.04.042. Epub 2013 Apr 24.
A limited amount of research suggests that oral ingestion of pinitol (3-O-methyl-d-chiro-inositol) positively influences glucose tolerance in humans. This study assessed the effects of different doses of pinitol supplementation on glucose tolerance, insulin sensitivity and plasma pinitol concentrations. Thirty healthy subjects underwent two one-day trials in which they consumed a nutritive beverage (Fruit Up®) containing 2.5, 4.0 or 6.0g of pinitol and a corresponding placebo equivalent in both energy and carbohydrates. Blood samples were collected frequently over the 240-min test period. The pinitol-enriched beverage reduced serum glucose and insulin at 45 and 60min, but only at a dose of 6.0g. Plasma pinitol concentrations, maximum concentration and AUC increased according to the dose administered. The results show that a single dose of pinitol from a naturally-occurring food ingredient at the highest dose administered acutely influences indices of whole-body glucose tolerance and insulin sensitivity in healthy subjects.
研究表明，口服肌醇（3-O-甲基-D-手性肌醇）可显著改善人体的葡萄糖耐量。 本研究评估了不同剂量肌醇补充剂对葡萄糖耐量、胰岛素敏感性和血浆肌醇浓度的影响。30 名健康受试者进行了两项为期一天的试验，他们分别摄入含有 2.5、4.0 或 6.0 克肌醇的营养饮料（Fruit Up®）和相应的能量和碳水化合物等效安慰剂。在 240 分钟的测试期间频繁采集血样。富含肌醇的饮料可降低 45 分钟和 60 分钟时的血清葡萄糖和胰岛素，但仅在 6.0 克剂量时有效。血浆肌醇浓度、最大浓度和 AUC 随给药剂量增加而增加。结果表明，单次摄入最高剂量的天然存在于食物中的肌醇可急性影响健康受试者的全身葡萄糖耐量和胰岛素敏感性的各项指标。
