缺氧、黑素细胞与黑色素瘤——皮肤宽松微环境中的生存与肿瘤发展
Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin.
作者信息
Bedogni Barbara, Powell Marianne Broome
机构信息
Division of Radiation and Cancer Biology, Stanford University, Stanford, CA, USA.
出版信息
Pigment Cell Melanoma Res. 2009 Apr;22(2):166-74. doi: 10.1111/j.1755-148X.2009.00553.x. Epub 2009 Feb 13.
Abstract
The tissue microenvironment plays a critical role in cell survival and growth and can contribute to cell transformation and tumor development. Cellular interactions with the stroma and with other cells provide key signals that control cellular arrest or division, survival or death, and entrance or exit from a quiescent state. Together, these decisions are essential for maintenance of tissue homeostasis. Tissue oxygenation is an important component of the microenvironment that can acutely alter the behavior of a cell through the direct regulation of genes involved in cell survival, apoptosis, glucose metabolism, and angiogenesis. Loss of tissue homeostasis due to, for example, oncogene activation leads to the disruption of these signals and eventually can lead to cell transformation and tumor development. Here we review the role of tissue oxygenation, and in particular physiologic skin hypoxia, on cell survival and senescence and how it contributes to melanocyte transformation and melanoma development.
摘要
组织微环境在细胞存活和生长中起着关键作用，并可促进细胞转化和肿瘤发展。细胞与基质以及其他细胞的相互作用提供了控制细胞停滞或分裂、存活或死亡以及进入或退出静止状态的关键信号。这些决定共同对于维持组织稳态至关重要。组织氧合是微环境的一个重要组成部分，它可通过直接调节参与细胞存活、凋亡、葡萄糖代谢和血管生成的基因来急性改变细胞行为。例如，由于癌基因激活导致的组织稳态丧失会破坏这些信号，并最终导致细胞转化和肿瘤发展。在这里，我们综述组织氧合，特别是生理性皮肤缺氧，对细胞存活和衰老的作用，以及它如何促进黑素细胞转化和黑色素瘤发展。
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