在艰难梭菌感染的人体肠道模型中，托氟沙星对细胞毒素的中和无效。
Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection.
作者信息
Baines Simon D, Freeman Jane, Wilcox Mark H
机构信息
Department of Microbiology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2009 May;53(5):2202-4. doi: 10.1128/AAC.01085-08. Epub 2009 Feb 17.
Abstract
The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.
摘要
研究了一种非抗菌性苯乙烯衍生物毒素结合剂托纳美在体外人肠道模型中治疗模拟艰难梭菌感染的疗效。托纳美既未缩短艰难梭菌细胞毒素活性的持续时间，也未降低其活性强度，这反映出在近期的III期临床试验中观察到的疗效不佳。
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