Kelly A, Powis S H, Glynne R, Radley E, Beck S, Trowsdale J
Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
Nature. 1991 Oct 17;353(6345):667-8. doi: 10.1038/353667a0.
Antgen processing involves the generation of peptides from cytosolic proteins and their transport into the endoplasmic reticulum where they associate with major histocompatibility complex (MHC) class I molecules. Two genes have been identified in the MHC class II region, RING4 and RING11 in humans, which are believed to encode the peptide transport proteins. Attention is now focused on how the transporters are provided with peptides. The proteasome, a large complex of subunits with multiple proteolytic activities, is a candidate for this function. Recently we reported a proteasome-related sequence, RING10, mapping between the transporter genes. Here we describe a second human proteasome-like gene, RING12, immediately centromeric of the RING4 locus. Therefore RING12, 4, 10 and 11 form a tightly linked cluster of interferon-inducible genes within the MHC with an essential role in antigen processing.
抗原加工涉及从胞质蛋白生成肽，并将其转运到内质网，在那里它们与主要组织相容性复合体（MHC）I类分子结合。在MHC II类区域已鉴定出两个基因，在人类中为RING4和RING11，它们被认为编码肽转运蛋白。现在注意力集中在如何为转运蛋白提供肽。蛋白酶体是一种具有多种蛋白水解活性的大型亚基复合物，是执行此功能的候选者。最近我们报道了一个与蛋白酶体相关的序列RING10，它定位于转运蛋白基因之间。在这里，我们描述了第二个类人蛋白酶体基因RING12，它紧挨着RING4基因座的着丝粒。因此，RING12、4、10和11在MHC内形成了一个紧密相连的干扰素诱导基因簇，在抗原加工中起重要作用。
