Qian Yufeng, Chen Bingqian, Sheng Xiaowen, Peng Yuqin
Changshu Hospital Affiliated to Soochow University, First People' s Hospital of Changshu City, Changshu, Jiangsu Province, China.
Medicine (Baltimore). 2019 Nov;98(45):e17804. doi: 10.1097/MD.0000000000017804.
Ankylosing spondylitis (AS) is one of the most common chronic inflammatory disorders affecting the sacroiliac joints, spine, and peripheral joints. Apart from HLA-B27, the LMP2 gene has been shown to play a role in the pathogenesis of AS as well as AAU in AS. However, genetic associations between LMP2 CfoI polymorphism and AS and AAU were inconclusive. We aimed to investigate the correlation of LMP2 CfoI polymorphism and AS and AAU using meta-analysis.
An exhaustive search was conducted using the PubMed, Embase, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) electronic databases. The strength association was assessed by crude ORs with 95% CI.
Eight eligible records with 449 AS patients and 317 healthy controls were included in the present study. The allelic model of the LMP2 CfoI polymorphism is associated with AS risk (OR = 0.60, 95%CI = [0.32, 1.11], P = .003). A stratified analysis based on ethnicity has shown that the allelic model of LMP2 CfoI was associated with AS in the Caucasian population (OR = 0.72, 95%CI = [0.55, 0.93], P = .01) but not in the Asian population (P > .05). Furthermore, no association was detected between LMP2 CfoI polymorphism and AS complication (AAU).
Our combined results revealed that the allelic model of LMP2 CfoI might be a protective factor for AS in the Caucasian population. Nevertheless, future studies on different ethnicities with larger sample sizes are needed to obtain a more convincing result.
强直性脊柱炎（AS）是影响骶髂关节、脊柱和外周关节的最常见慢性炎症性疾病之一。除HLA - B27外，LMP2基因已被证明在AS的发病机制以及AS中的急性前葡萄膜炎（AAU）中起作用。然而，LMP2 CfoI多态性与AS和AAU之间的遗传关联尚无定论。我们旨在通过荟萃分析研究LMP2 CfoI多态性与AS和AAU的相关性。
使用PubMed、Embase、Cochrane图书馆和中国国家知识基础设施（CNKI）电子数据库进行全面检索。通过带有95%置信区间的粗比值比（OR）评估关联强度。
本研究纳入了8篇符合条件的记录，包括449例AS患者和317例健康对照。LMP2 CfoI多态性的等位基因模型与AS风险相关（OR = 0.60，95%CI = [0.32, 1.11]，P = 0.003）。基于种族的分层分析表明，LMP2 CfoI的等位基因模型在白种人群中与AS相关（OR = 0.72，95%CI = [0.55, 0.93]，P = 0.01），而在亚洲人群中则无相关性（P > 0.05）。此外，未检测到LMP2 CfoI多态性与AS并发症（AAU）之间存在关联。
我们的综合结果表明，LMP2 CfoI的等位基因模型可能是白种人群中AS的一个保护因素。然而，需要对不同种族进行更大样本量的未来研究以获得更有说服力的结果。
