Syuto Tomoko, Shimizu Akira, Takeuchi Yuko, Tanaka Setsuko, Hasegawa Michiko, Nagai Yayoi, Tamura Atsushi, Ishikawa Osamu
Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Clin Rheumatol. 2009 Jul;28(7):841-5. doi: 10.1007/s10067-009-1123-1. Epub 2009 Feb 18.
Neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are well-recognized symptoms although the pathophysiology of neuropsychiatric SLE (NPSLE) is unclear. Since an association with antiphospholipid antibodies has been reported, we examined the prevalence of antiphosphatidylserine-prothrombin antibodies (anti-PS/PT Abs), lupus anticoagulant (LA), anticardiolipin/beta2-glycoprotein I antibodies (anti-beta2-GPI Abs), and antiribosomal P protein antibodies (antiribosomal P Abs) in 68 SLE patients and analyzed their associations with neuropsychiatric manifestations. The prevalence of LA was significantly higher in the patients with neuropsychiatric (NP) features than those without NP features (P < 0.02). The levels of anti-PS/PT antibody were also significantly higher in the patients with NP features than those without NP features (P < 0.01). The results indicate that LA positivity and higher levels of anti-PS/PT antibody can be predictive markers for NPSLE.
系统性红斑狼疮（SLE）患者的神经精神表现是公认的症状，尽管神经精神性狼疮（NPSLE）的病理生理学尚不清楚。由于已有报道称其与抗磷脂抗体有关联，我们检测了68例SLE患者中抗磷脂酰丝氨酸 - 凝血酶原抗体（抗PS/PT抗体）、狼疮抗凝物（LA）、抗心磷脂/β2-糖蛋白I抗体（抗β2-GPI抗体）和抗核糖体P蛋白抗体（抗核糖体P抗体）的患病率，并分析了它们与神经精神表现的关联。有神经精神（NP）特征的患者中LA的患病率显著高于无NP特征的患者（P < 0.02）。有NP特征的患者中抗PS/PT抗体水平也显著高于无NP特征的患者（P < 0.01）。结果表明，LA阳性和抗PS/PT抗体水平升高可作为NPSLE的预测指标。
