Stasiak Magdalena, Lewiński Andrzej, Karbownik-Lewińska Małgorzata
Klinika Endokrynologii i Chorób Metabolicznych, Instytut Centrum Zdrowia Matki Polki, Łodź.
Endokrynol Pol. 2009 Jan-Feb;60(1):40-50.
Potassium bromate (KBrO(3)) is a compound belonging to Group 2B of carcinogens (a possible human carcinogen). This agent was used as a food additive in flour treatment, as a component of cold-wave hair lotions, and is still used in barley processing. Additionally, KBrO(3) is formed as an oxyhalide by-product during water ozonation. KBrO(3) induces oxidative stress and may contribute to neoplasia in endocrine glands. It has been demonstrated that KBrO(3) triggers thyroid follicular cell tumors in rats. It has been revealed in our in vivo and in vitro studies that KBrO(3) significantly increases lipid peroxidation in rat and porcine thyroid. KBrO(3) also induces mesotheliomas which may secrete hormones or similar substances, such as parathyroid hormone related protein, phosphatonins or melanocyte stimulating hormone. In our experimental studies we demonstrated that antioxidants, such as pineal hormone - melatonin, indole-3-propionic acid (IPA) (a compound chemically and physically similar to melatonin) and antythyroid drug - propylthiouracil (PTU), produce distinct protective effects against lipid peroxidation due to KBrO(3) in the thyroid in vivo. KBrO(3) is a prooxidant which may induce neoplasia in endocrine glands and cause hormonal disturbances, however its damaging effects may be neutralized by hormones, mainly melatonin.
溴酸钾（KBrO₃）是2B类致癌物（一种可能的人类致癌物）中的一种化合物。该物质曾用作面粉处理中的食品添加剂、冷烫液的成分，目前仍用于大麦加工。此外，在水的臭氧化过程中，溴酸钾会作为卤氧化物副产物形成。溴酸钾会引发氧化应激，可能导致内分泌腺肿瘤形成。已证实溴酸钾会诱发大鼠甲状腺滤泡细胞肿瘤。我们的体内和体外研究表明，溴酸钾会显著增加大鼠和猪甲状腺中的脂质过氧化。溴酸钾还会诱发间皮瘤，间皮瘤可能分泌激素或类似物质，如甲状旁腺激素相关蛋白、磷调节素或促黑素细胞激素。在我们的实验研究中，我们证明了抗氧化剂，如松果体激素——褪黑素、吲哚 - 3 - 丙酸（IPA）（一种在化学和物理性质上与褪黑素相似的化合物）以及抗甲状腺药物——丙硫氧嘧啶（PTU），在体内对甲状腺中由溴酸钾引起的脂质过氧化具有明显的保护作用。溴酸钾是一种促氧化剂，可能诱发内分泌腺肿瘤并导致激素紊乱，然而其破坏作用可能被主要是褪黑素的激素中和。
