de Jong G M, Boerman O C, Heskamp S, Aarts F, Bleichrodt R P, Hendriks T
Department of Surgery, Division of Oncology and Abdominal Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Br J Surg. 2009 Mar;96(3):314-21. doi: 10.1002/bjs.6481.
Radioimmunotherapy (RIT) is suitable for the treatment of microscopic residual disease and might therefore have an adjuvant role after colonic cancer surgery.
An anastomosis was constructed in male Wag/Rij rats after intraluminal injection of 2 x 10(6) CC531 tumour cells. The biodistribution of (111)In-labelled MG1 monoclonal antibody was assessed after intraperitoneal administration. The therapeutic efficacy of (177)Lu-labelled MG1 (74 MBq per rat), administered on the day of surgery (D0, n = 13) or 5 days later (D5, n = 13), was compared with that of carrier only (n = 13). The primary endpoint was perianastomotic tumour growth 28 days after surgery.
(111)In-labelled MG1 preferentially accumulated in perianastomotic CC531 tumours. RIT resulted in a transient reduction in bodyweight in both treatment groups compared with controls, but there were no other signs of clinical discomfort. No macroscopic or microscopic perianastomotic tumour growth was found in eight of 11 animals in the D0 group and 11 of 13 in the D5 group, whereas 11 of 13 controls had macroscopic tumour (P = 0.011 and P = 0.001 respectively).
This study suggests that RIT may be an effective adjuvant treatment for preventing local recurrence after resection of colonic cancer.
放射免疫疗法（RIT）适用于治疗微小残留病灶，因此可能在结肠癌手术后具有辅助治疗作用。
在雄性Wag/Rij大鼠肠腔内注射2×10⁶个CC531肿瘤细胞后构建吻合口。腹腔注射后评估¹¹¹In标记的MG1单克隆抗体的生物分布。将手术当天（D0，n = 13）或5天后（D5，n = 13）给予的¹⁷⁷Lu标记的MG1（每只大鼠74 MBq）的治疗效果与仅给予载体的情况（n = 13）进行比较。主要终点是术后28天吻合口周围肿瘤的生长情况。
¹¹¹In标记的MG1优先在吻合口周围的CC531肿瘤中蓄积。与对照组相比，两个治疗组的RIT均导致体重短暂下降，但没有其他临床不适迹象。D0组11只动物中有8只以及D5组13只动物中有11只未发现吻合口周围有宏观或微观肿瘤生长，而13只对照组中有11只出现宏观肿瘤（分别为P = 0.011和P = 0.001）。
本研究表明，RIT可能是预防结肠癌切除术后局部复发的一种有效辅助治疗方法。
