INSIG2 和 FTO 对一年生活方式干预减重的加重作用。
Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention.
机构信息
Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany.
出版信息
Arch Dis Child. 2009 Dec;94(12):965-7. doi: 10.1136/adc.2008.147652. Epub 2009 Feb 17.
OBJECTIVE
Obesity is considered a polygenic and multifactorial disorder and different single nucleotide polymorphisms (SNP) are involved. Studies concerning their impact on weight loss in lifestyle intervention are scarce.
METHODS
The effect of two different SNP (INSIG2: rs7566605, FTO: rs9939609) was analysed on the change of weight status in a one-year lifestyle intervention among 280 overweight children (mean age 10.8 years, mean body mass index (BMI) 28.1 kg/m(2)).
RESULTS
The children reduced their mean SDS-BMI by -0.28 (95% CI -0.32 to -0.23). Modelling the impact of different genotypes and their statistical interactions on SDS-BMI change adjusting for age, gender and baseline BMI or SDS-BMI, respectively, revealed that the combination of the CC genotype in INSIG2 and the AA genotype in FTO was significantly associated with the lowest degree of overweight reduction, but even with an increase in overweight (SDS-BMI change +0.51; 95% CI 0.22 to 0.79).
CONCLUSIONS
These findings provide some evidence that the effects of different genotypes aggravate each other concerning weight change.
目的
肥胖被认为是一种多基因和多因素的疾病，涉及不同的单核苷酸多态性（SNP）。关于它们对生活方式干预减肥效果的研究很少。
方法
在一项为期一年的生活方式干预中，分析了两种不同 SNP（INSIG2：rs7566605，FTO：rs9939609）对 280 名超重儿童体重状况变化的影响（平均年龄 10.8 岁，平均体重指数（BMI）28.1kg/m2）。
结果
儿童的平均 SDS-BMI 降低了-0.28（95%置信区间-0.32 至-0.23）。分别调整年龄、性别和基线 BMI 或 SDS-BMI 后，对不同基因型及其统计相互作用对 SDS-BMI 变化的影响进行建模，结果表明 INSIG2 的 CC 基因型和 FTO 的 AA 基因型的组合与超重减轻的程度最低显著相关，但即使超重增加（SDS-BMI 变化+0.51；95%置信区间 0.22 至 0.79）。
结论
这些发现提供了一些证据，表明不同基因型的作用相互加重，影响体重变化。
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