Department of Pediatrics-Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Am J Clin Nutr. 2010 Feb;91(2):321-8. doi: 10.3945/ajcn.2009.28186. Epub 2009 Dec 9.
Overweight is a complex trait in which both environmental and genetic factors play a role.
We aimed to evaluate the influence of common genetic variants identified by genome-wide association studies on overweight and the metabolic profile in adolescence.
In a population-based cohort of 663 girls and 612 boys aged 16 y, weight, height, skinfold thicknesses, percentage body fat, waist circumference, blood pressure, glucose, insulin, lipid profile, and DNA were obtained. We defined overweight according to international criteria. We performed multiple linear and logistic regression analyses to assess the influence of candidate single nucleotide polymorphisms near the INSIG2, in the FTO, and near the MC4R genes and repeated-measures analyses of available body mass index (BMI) and skinfold thickness data across 3 visits at ages 11, 13.5, and 16 y.
A total of 15.1% of participants were overweight or obese at age 16 y. No associations with INSIG2 were found. Common variation in the FTO gene was associated with sex-specific z scores of BMI (B: 0.11; 95% CI: 0.03, 0.19), sum of skinfold thicknesses (B: 0.12; 95% CI: 0.04, 0.20), percentage body fat (B: 0.11; 95% CI: 0.03, 0.19), waist circumference (B: 0.11; 95% CI: 0.03, 0.19), fasting glucose (B: 0.10; 95% CI: 0.00, 0.20), and overweight (odds ratio: 1.34; 95% CI: 1.06, 1.69) at age 16 y. Repeated-measures analyses confirmed the associations for BMI and sum of skinfold thicknesses, and physical activity did not modify these associations. Common variation near the MC4R gene was associated with BMI in cross-sectional (B: 0.11; 95% CI: 0.02, 0.20) and repeated-measures (B: 0.12; 95% CI: 0.03, 0.20) analyses.
Common variation in the FTO gene is associated with overall and abdominal adiposity. Variation near the MC4R gene is associated with BMI. These findings in adolescents strengthen and extend the results from previous research.
超重是一种复杂的特征，其中环境和遗传因素都起着作用。
我们旨在评估通过全基因组关联研究鉴定的常见遗传变异对超重和青春期代谢特征的影响。
在一个基于人群的 663 名女孩和 612 名 16 岁男孩的队列中，获取体重、身高、皮褶厚度、体脂百分比、腰围、血压、血糖、胰岛素、血脂谱和 DNA。我们根据国际标准定义超重。我们进行了多元线性和逻辑回归分析，以评估 INSIG2 附近候选单核苷酸多态性、FTO 基因附近和 MC4R 基因附近的遗传变异对超重和青春期代谢特征的影响，并对 11 岁、13.5 岁和 16 岁时 3 次就诊的可用体重指数（BMI）和皮褶厚度数据进行重复测量分析。
共有 15.1%的参与者在 16 岁时超重或肥胖。INSIG2 没有发现与超重相关的关联。FTO 基因的常见变异与 BMI 的性别特异性 z 评分（B：0.11；95%CI：0.03，0.19）、皮褶厚度总和（B：0.12；95%CI：0.04，0.20）、体脂百分比（B：0.11；95%CI：0.03，0.19）、腰围（B：0.11；95%CI：0.03，0.19）、空腹血糖（B：0.10；95%CI：0.00，0.20）和 16 岁时超重（比值比：1.34；95%CI：1.06，1.69）有关。重复测量分析证实了 BMI 和皮褶厚度总和的关联，而体力活动并没有改变这些关联。MC4R 基因附近的常见变异与横断面（B：0.11；95%CI：0.02，0.20）和重复测量（B：0.12；95%CI：0.03，0.20）分析中的 BMI 有关。
FTO 基因的常见变异与整体和腹部肥胖有关。MC4R 基因附近的变异与 BMI 有关。这些在青少年中的发现加强并扩展了之前研究的结果。
