一种用于对具有整合素α(v)β(3)的肿瘤细胞进行靶向成像的光稳定荧光探针。
A photostable fluorescent probe for targeted imaging of tumour cells possessing integrin alpha(v)beta(3).
作者信息
Xiong Liqin, Yu Mengxiao, Cheng Mingjun, Zhang Meng, Zhang Xiaoyan, Xu Congjian, Li Fuyou
机构信息
Department of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China.
出版信息
Mol Biosyst. 2009 Mar;5(3):241-3. doi: 10.1039/b820576k. Epub 2009 Jan 7.
DOI:10.1039/b820576k
PMID:19225614
Abstract
A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence.
摘要
一步S(N)Ar(H)反应已用于合成具有良好水溶性和低细胞毒性的光稳定探针；该探针可凭借整联蛋白α(v)β(3)与精氨酸-甘氨酸-天冬氨酸三肽序列之间的特异性结合用于肿瘤细胞的靶向成像。
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