Timmer R, Koningsberger J C, Erkelens D W, Thijssen J H, Lips C J, Koppeschaar H P
Department of Internal Medicine and Endocrinology, University Hospital Utrecht, The Netherlands.
Neth J Med. 1991 Jun;38(5-6):199-203.
The efficacy of subchronic (3 weeks) treatment with the long-acting somatostatin analogue octreotide was studied in four patients with symptomatic benign insulinoma. No clinical or biochemical effect on serum glucose, insulin, C-peptide or glucagon was observed in all four patients despite clearly detectable serum levels of octreotide. The resistance to octreotide therapy in these patients might be explained by the absence of somatostatin analogue receptors on their tumours.
