锝-99m-甲氧基异丁基异腈闪烁扫描术在评估肝细胞生长因子基因治疗对下肢动脉硬化闭塞症疗效中的应用

Tc-99m-MIBI scintigraphy in evaluating the effect of hepatocyte growth factor gene therapy for peripheral arteriosclerosis obliterans.

作者信息

Yamagami Takuji, Kanda Keiichi, Okuyama Chio, Nishimura Tsunehiko

机构信息

Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

出版信息

Ann Nucl Med. 2009 Feb;23(2):205-8. doi: 10.1007/s12149-008-0220-6. Epub 2009 Feb 19.

DOI:10.1007/s12149-008-0220-6

PMID:19225945

Abstract

We report an 81-year-old man with arteriosclerosis obliterans with sharp rest pain of the left lower leg below the knee that was resistant to conventional drug therapy. Gene therapy using hepatocyte growth factor (HGF) was performed, following which the symptoms remarkably improved. Magnetic resonance (MR) angiography did not detect any development of collateral vessels following gene therapy; however, technetium-99m-methoxyisobutylisonitrile (Tc-99m)-MIBI scintigraphy revealed the development of micro-circulation in the lower leg following HGF gene therapy. This is the first report on the usefulness of Tc-99m-MIBI scintigraphy to evaluate the effectiveness of HGF gene therapy for peripheral arteriosclerosis obliterans.

摘要

我们报告了一名81岁患有闭塞性动脉硬化的男性，其左小腿膝盖以下部位存在剧烈的静息痛，对传统药物治疗无效。采用肝细胞生长因子（HGF）进行了基因治疗，随后症状显著改善。基因治疗后，磁共振（MR）血管造影未检测到侧支血管的形成；然而，锝-99m-甲氧基异丁基异腈（Tc-99m）-MIBI闪烁显像显示，HGF基因治疗后小腿出现了微循环。这是首篇关于利用Tc-99m-MIBI闪烁显像评估HGF基因治疗外周闭塞性动脉硬化有效性的报道。