Stojsic Zorica, Brasanac Dimitrije, Kokai George, Vujovic Dragana, Zivanovic Dragana, Boricic Ivan, Bacetic Dragoljub
Institute of Pathology, University of Belgrade, Serbia.
Turk J Pediatr. 2008 Nov-Dec;50(6):600-3.
Pyogenic granuloma (PG), also known as lobular capillary hemangioma, is a benign vascular tumor, most commonly arising on the skin and the oral mucosa. Gastrointestinal localization of PG, except for the oral cavity, is exceptionally rare. We describe a case of ileal PG occurring in a 13-year-old girl, presenting with intestinal obstruction. Histological examination revealed proliferation of capillary-sized vessels, with prominent intravascular component, involving the entire thickness of the intestinal wall. Immunohistochemistry showed positivity for CD31, CD34 and von Willebrand factor, whereas immunostaining for glucose transporter-1 protein (GLUT1) and for human herpes virus 8 (HHV-8) was negative. We suggest that PG should be considered in the differential diagnosis of childhood gastrointestinal polypoid lesions.
化脓性肉芽肿（PG），也称为小叶性毛细血管瘤，是一种良性血管肿瘤，最常见于皮肤和口腔黏膜。除口腔外，PG在胃肠道的定位极为罕见。我们报告一例发生在一名13岁女孩的回肠PG，表现为肠梗阻。组织学检查显示毛细血管大小的血管增生，血管内成分突出，累及肠壁全层。免疫组化显示CD31、CD34和血管性血友病因子呈阳性，而葡萄糖转运蛋白-1（GLUT1）和人类疱疹病毒8（HHV-8）免疫染色为阴性。我们建议在儿童胃肠道息肉样病变的鉴别诊断中应考虑PG。
