Bernardini R, Pecora S, Milani M, Burastero S E
Paediatric Allergy and Pneumology Centre, Anna Meyer Children's Hospital, Florence, Italy.
Eur Ann Allergy Clin Immunol. 2008 Dec;40(4):142-7.
We previously demonstrated that one year of sublingual immunotherapy (SLIT) with natural rubber latex (NRL) was safe and efficacious in paediatric patients with NRL allergy.
We studied 12 NRL-allergic children (age 4-15), previously assigned to the treated arm of a double-blind placebo controlled study, who received a commercial latex SLIT for three years. Adverse reactions were monitored. The primary end-point was the NRL glove-use test. As secondary end-points, skin prick test with NRL and NRL serum specific IgE were used.
No SLIT-related side effects were observed. A significant reduction of the glove-use score was observed after one-year treatment (5.1 +/- 4.2 vs. 14.8 +/- 5.7, p=0.0031). This parameter was further reduced in the second year since SLIT start (2.0 +/- 2.7, p=000007). After 3 years of SLIT all patients had a negative glove-use test (p<0.0001). Baseline wheal areas of skin prick test (6.8 +/- 2.5 mm2) were significantly reduced after 2 (5.3 +/- 1.8 mm2) and 3 years (4.0 +/- 1.8 mm2) of SLIT (p=0.039 and 0.027, respectively). Baseline values of serum specific IgE (23 +/- 34 KU/l) were significantly reduced after 3 years since SLIT start (6.4 +/- 5.0, p=0.0371).
Three years of latex SLIT is safe and consolidates the efficacy previously observed after one year of treatment in paediatric patients.
我们之前证明，对天然橡胶乳胶（NRL）过敏的儿科患者进行为期一年的舌下免疫疗法（SLIT）是安全有效的。
我们研究了12名对NRL过敏的儿童（年龄4 - 15岁），这些儿童之前被分配到一项双盲安慰剂对照研究的治疗组，接受了三年的商用乳胶SLIT治疗。监测不良反应。主要终点是NRL手套使用测试。作为次要终点，使用了NRL皮肤点刺试验和NRL血清特异性IgE。
未观察到与SLIT相关的副作用。治疗一年后，手套使用评分显著降低（5.1±4.2对14.8±5.7，p = 0.0031）。自开始SLIT治疗的第二年，该参数进一步降低（2.0±2.7，p = 0.000007）。经过3年的SLIT治疗，所有患者的手套使用测试均为阴性（p < 0.0001）。SLIT治疗2年（5.3±1.8 mm²）和3年（4.0±1.8 mm²）后，皮肤点刺试验的基线风团面积（6.8±2.5 mm²）显著减小（分别为p = 0.039和0.027）。自开始SLIT治疗3年后，血清特异性IgE的基线值（23±34 KU/l）显著降低（6.4±5.0，p = 0.0371）。
三年的乳胶SLIT治疗是安全的，并巩固了之前在儿科患者一年治疗后观察到的疗效。
