Nagao Mie, Sato Takashi, Akimoto Noriko, Kato Yuya, Takahashi Masao, Ito Akira
Exp Dermatol. 2009 Aug;18(8):730-3. doi: 10.1111/j.1600-0625.2008.00831.x. Epub 2009 Feb 18.
Grifola frondosa (Maitake mushroom) is an edible and medicinal mushroom with versatile effects such as antitumor and immunomodulating actions. Here, we demonstrated that an ethanol extract of G. frondosa fruiting body (Maitake extract) augmented intracellular lipid droplet formation and the production of triacylglycerols (TG), a major component of sebum, along with the activation of diacylglycerol acyltransferase, a rate-limiting enzyme of TG synthesis in cultured hamster sebocytes. The topical treatment of Maitake extract on the skin of hamster auricles augmented sebum accumulation in sebaceous glands and ducts. However, in comparison with the Maitake extract, another ethanol extract prepared from Agaricus blazei Murill showed less activity in sebaceous lipogenesis in hamsters in vivo and in vitro. These results provide novel evidence that Maitake extract augments sebaceous lipogenesis in hamsters in vivo and in vitro. Thus, Maitake extract is likely to be a unique agent leading to the remission of dry skin.
灰树花（舞茸）是一种具有抗肿瘤和免疫调节等多种功效的食药用菌。在此，我们证明了灰树花子实体的乙醇提取物（舞茸提取物）可增加细胞内脂质滴的形成以及三酰甘油（TG）的产生，TG是皮脂的主要成分，同时还能激活二酰甘油酰基转移酶，该酶是培养的仓鼠皮脂腺细胞中TG合成的限速酶。将舞茸提取物局部涂抹于仓鼠耳廓皮肤可增加皮脂腺和导管中的皮脂积累。然而，与舞茸提取物相比，另一种从姬松茸制备的乙醇提取物在体内和体外对仓鼠皮脂腺脂质生成的活性较低。这些结果提供了新的证据，表明舞茸提取物在体内和体外均可增加仓鼠的皮脂腺脂质生成。因此，舞茸提取物可能是一种导致干性皮肤缓解的独特药物。
