Casse Guillaume, Adenis Jean-Paul, Sauvage Jean-Pierre, Robert Pierre-Yves
Ophthalmology Department, CHU Dupuytren, Cedex, France.
Orbit. 2009;28(1):20-4. doi: 10.1080/01676830802541004.
Apply a videonystagmography (VNG) device to study indirectly blinking in patients with essential blepharospasm.
A VNG device was used to study the pupillary occlusion. It was recorded and analyzed as indirect parameters of blinking in 23 essential blepharospasm on day 0, month 1, and month 3 following botulinum toxin injection using VNG.
Botulinum toxin significantly reduced pupillary occlusions (PO) frequency (9.6 PO/min on D0 and 4.7 PO/min on M1 (p = 0.004), and average PO time (0.95 sec on D0 and 0.58 sec on M1 (p = 0.03) for PO higher than 0.3 sec. On the other hand, it does not have any action on frequency (32.4 PO/min on D0 and 31.3 PO/min on M1 (p = 0.7) and average PO time (0.16 sec on D0 and 0.15 sec on M1 (p = 0.4) of PO lower than 0.3 sec.
Video acquisition computer-assisted makes it possible to measure blinking parameters indirectly in real time and to assess essential blepharospasm objectively. The protocol analysis of PO is attractive for indirect analysis of blinking.
应用视频眼震图（VNG）设备间接研究特发性眼睑痉挛患者的眨眼情况。
使用VNG设备研究瞳孔阻滞情况。在肉毒杆菌毒素注射后的第0天、第1个月和第3个月，对23例特发性眼睑痉挛患者的瞳孔阻滞情况进行记录并作为眨眼的间接参数进行分析。
肉毒杆菌毒素显著降低了瞳孔阻滞（PO）频率（第0天为9.6次/分钟，第1个月为4.7次/分钟（p = 0.004）），对于持续时间高于0.3秒的PO，平均PO时间也显著降低（第0天为0.95秒，第1个月为0.58秒（p = 0.03））。另一方面，对于持续时间低于0.3秒的PO，肉毒杆菌毒素对其频率（第0天为32.4次/分钟，第1个月为31.3次/分钟（p = 0.7））和平均PO时间（第0天为0.16秒，第1个月为0.15秒（p = 0.4））没有任何影响。
视频采集计算机辅助技术使得实时间接测量眨眼参数并客观评估特发性眼睑痉挛成为可能。PO的协议分析对于眨眼的间接分析具有吸引力。
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