Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia.
Mol Immunol. 2009 Nov;47(1):19-27. doi: 10.1016/j.molimm.2009.01.007. Epub 2009 Feb 23.
Although TNF has been discovered due to anti-tumor activity, its physiological functions are different. Current knowledge places TNF downstream of many receptors of innate immunity, implying its primary role in host defense and inflammation. When overproduced systemically or locally, TNF may exert deleterious effects on the organism. Anti-TNF therapy is highly efficient in several autoimmune and inflammatory diseases. However, due to TNF unique beneficial functions in immune system, such therapy cannot be entirely free of adverse effects. We review the current status of the field with the focus on drugs and strategies used for TNF ablation in vivo.
虽然 TNF 是由于抗肿瘤活性而被发现的，但它的生理功能是不同的。目前的知识将 TNF 置于先天免疫的许多受体的下游，这意味着它在宿主防御和炎症中起着主要作用。当 TNF 在全身或局部过度产生时，可能对机体产生有害影响。抗 TNF 治疗在几种自身免疫和炎症性疾病中非常有效。然而，由于 TNF 在免疫系统中具有独特的有益功能，因此这种治疗方法不可能完全没有不良反应。我们综述了该领域的现状，重点介绍了用于体内 TNF 消融的药物和策略。
