Polzin W J, Kopelman J N, Brady K, Read J A
Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington.
Obstet Gynecol. 1991 Oct;78(4):600-1.
The purpose of our investigation was to determine the prevalence of illicit drug use within our socioeconomically heterogeneous obstetric population, in order to assess the need for institution of universal screening. Five hundred consecutive new obstetric registrants had urine collected for routine culture. Following removal of a small aliquot of urine for culture, the samples were sent to the Armed Forces Institute of Pathology, Division of Forensic Toxicology. Each specimen was screened for the presence of alcohol, cocaine metabolites, cannabinoids, opiates, and amphetamines using fluorescent polarization immunoassay techniques. All positive screening tests were confirmed by gas chromatography mass spectrometry. Thirty samples were either lost in processing or of insufficient quantity to test. Five of the 470 samples (1.06%) tested were positive. One subject was taking prescription narcotics, so the correlated prevalence was 0.85%. Three tested positive for tetrahydrocannabinol and two for opiates. Analysis of our data demonstrates that our obstetric population has a significantly lower prevalence of illicit drug use than other populations reported previously (P less than .01). We recommend that each institution providing obstetric services determine its specific prevalence of illicit drug use.
我们调查的目的是确定在我们社会经济背景各异的产科人群中非法药物使用的流行情况,以便评估开展普遍筛查的必要性。连续500名新登记的产科患者的尿液被收集用于常规培养。在取出一小份尿液用于培养后,样本被送往武装部队病理研究所法医毒理学部。使用荧光偏振免疫分析技术对每个样本进行酒精、可卡因代谢物、大麻素、阿片类药物和苯丙胺类物质检测。所有筛查呈阳性的检测均通过气相色谱质谱法进行确认。30个样本在处理过程中丢失或数量不足无法检测。470个检测样本中有5个(1.06%)呈阳性。一名受试者正在服用处方类麻醉药品,因此相关流行率为0.85%。3个样本四氢大麻酚检测呈阳性,2个样本阿片类药物检测呈阳性。对我们数据的分析表明,我们产科人群中非法药物使用的流行率明显低于先前报道的其他人群(P<0.01)。我们建议每个提供产科服务的机构确定其非法药物使用的具体流行率。