Vaughn A J, Carzoli R P, Sanchez-Ramos L, Murphy S, Khan N, Chiu T
Department of Pediatrics, University of Florida Health Science Center, Jacksonville.
Obstet Gynecol. 1993 Jul;82(1):92-6.
To determine the community-wide prevalence of illicit drug use in delivering women and to compare rates in women delivering in an urban center serving the medically indigent with those delivering in private hospitals.
Over 6 weeks, 1062 urine samples were obtained anonymously from women presenting for delivery in seven hospitals in the Jacksonville, Florida area. All urine samples were analyzed blindly for illicit drugs using fluorescent polarized immunoassay.
The percentage of women with positive urine toxicology was 7.1%. Positive results were more frequent in the public hospital population (12.7%) than the private hospital population (3.9%). The prevalence of cocaine use was 2.1% and marijuana 5.3%. Urine positivity was similar in black and white women, with cocaine metabolites more prevalent in black women and cannabinoids more common in white women. Women with positive screens for cocaine were more likely to use tobacco and alcohol, admit to substance abuse, and receive limited prenatal care. Women with positive screens for marijuana were difficult to differentiate from the urine-toxicology-negative group.
Urine samples positive for illicit drugs were significantly more common in women delivering in an urban center serving the indigent population than in those delivering in private hospitals. Based on associated factors, cocaine users fit a more indentifiable profile than marijuana users. The overall incidence of positive urine toxicology was no different in black and white pregnant women, but the more frequent finding of cocaine metabolites in black women may lead to biased over-reporting of substance abuse in this population.
确定分娩女性中非法药物使用的社区患病率,并比较在为医疗贫困人群服务的城市中心医院分娩的女性与在私立医院分娩的女性的患病率。
在6周多的时间里,从佛罗里达州杰克逊维尔地区7家医院中前来分娩的女性中匿名采集了1062份尿液样本。所有尿液样本均采用荧光偏振免疫分析法对非法药物进行盲法分析。
尿液毒理学检测呈阳性的女性比例为7.1%。公立医院人群中的阳性结果(12.7%)比私立医院人群(3.9%)更常见。可卡因使用的患病率为2.1%,大麻为5.3%。黑人和白人女性的尿液阳性率相似,可卡因代谢物在黑人女性中更普遍,大麻素在白人女性中更常见。可卡因筛查呈阳性的女性更有可能使用烟草和酒精,承认有药物滥用问题,并接受有限的产前护理。大麻筛查呈阳性的女性与尿液毒理学检测呈阴性的组难以区分。
在为贫困人群服务的城市中心医院分娩的女性中,非法药物检测呈阳性的尿液样本比在私立医院分娩的女性中显著更常见。基于相关因素,可卡因使用者比大麻使用者更符合可识别的特征。黑人和白人孕妇尿液毒理学检测呈阳性的总体发生率没有差异,但黑人女性中更频繁地发现可卡因代谢物可能导致该人群药物滥用报告存在偏差。