Sharmini Ahmad Tajudin Liza, Yin Nancy Yuen Shi, Lee Shami Shi-Huang, Jackson Angi L, Stewart William C
School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
J Ocul Pharmacol Ther. 2009 Feb;25(1):71-5. doi: 10.1089/jop.2008.0061.
The aim of this study was to evaluate risk factors for progression in chronic angle-closure glaucoma (CACG) patients.
A retrospective cohort of patient records in East Asia were evaluated for risk factors associated with progressive optic-disc and visual-field loss. There were 101 CACG patients with 5 years of follow-up.
Seventy-one percent (71%) of patients with intraocular pressures (IOP) of >22 mmHg progressed, whereas 26% of patients with IOPs of 13-21 mmHg progressed, and 0% of patients with IOPs of <12 mmHg progressed. The mean IOP was 16.6 +/- 3.4 mmHg in the stable group and 18.8 +/- 3.5 mmHg in the progressed group (P = 0.007). The highest average peak IOP was 23.2 +/- 6.3 mmHg in the stable group and 26.5 +/- 6.5 mmHg in the progressed group (P = 0.03). Generally, patients whose standard deviation of IOP was <2 mmHg (12% progressed) were more often stable, compared to those who were >3 mmHg (33% progressed). A multivariate regression analysis was positive for mean IOP as a clinically important risk factor for progression.
IOP reduction in CACG patients may help prevent progressive visual-field and optic-disc damage.
本研究旨在评估慢性闭角型青光眼（CACG）患者病情进展的危险因素。
对东亚地区患者记录的回顾性队列进行评估，以确定与视神经盘和视野渐进性丧失相关的危险因素。共有101例CACG患者接受了5年的随访。
眼压（IOP）>22 mmHg的患者中有71%病情进展，而眼压在13 - 21 mmHg的患者中有26%病情进展，眼压<12 mmHg的患者中无病情进展。稳定组的平均眼压为16.6 +/- 3.4 mmHg，进展组为18.8 +/- 3.5 mmHg（P = 0.007）。稳定组的最高平均眼压峰值为23.2 +/- 6.3 mmHg，进展组为26.5 +/- 6.5 mmHg（P = 0.03）。一般来说，眼压标准差<2 mmHg的患者（12%病情进展）比眼压标准差>3 mmHg的患者（33%病情进展）更常处于病情稳定状态。多因素回归分析显示平均眼压是病情进展的一个重要临床危险因素。
降低CACG患者的眼压可能有助于预防视野和视神经盘的渐进性损害。
