同种异体子宫内膜再生细胞的可行性研究。
Feasibility investigation of allogeneic endometrial regenerative cells.
作者信息
Zhong Zhaohui, Patel Amit N, Ichim Thomas E, Riordan Neil H, Wang Hao, Min Wei-Ping, Woods Erik J, Reid Michael, Mansilla Eduardo, Marin Gustavo H, Drago Hugo, Murphy Michael P, Minev Boris
机构信息
Medistem Inc, San Diego, USA.
出版信息
J Transl Med. 2009 Feb 20;7:15. doi: 10.1186/1479-5876-7-15.
Abstract
Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses. In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis treated intravenously and intrathecally. The case with the longest follow up, of more than one year, revealed no immunological reactions or treatment associated adverse effects. These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type.
摘要
子宫内膜再生细胞（ERC）是一群具有多能分化活性和诱导新血管生成能力的间充质样干细胞。体外和动物研究表明，ERC具有免疫特权，在某些情况下能积极抑制正在进行的免疫反应。在本文中，我们描述了临床级ERC的生产以及4例接受静脉和鞘内注射治疗的多发性硬化症患者的初步安全性经验。随访时间最长超过一年的病例未发现免疫反应或与治疗相关的不良反应。这些初步数据表明临床应用ERC具有可行性，并支持对这种新型干细胞类型进行进一步研究。
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本文引用的文献
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J Transl Med. 2008 Aug 19;6:45. doi: 10.1186/1479-5876-6-45.
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Transplantation of autologous bone marrow mononuclear cells for patients with lower limb ischemia.自体骨髓单个核细胞移植治疗下肢缺血患者。
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In vitro transdifferentiation of adult hematopoietic stem cells: an alternative source of engraftable hepatocytes.成人造血干细胞的体外转分化：可移植肝细胞的另一种来源。
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