Baines Christopher P
Department of Biomedical Sciences, Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
J Mol Cell Cardiol. 2009 Jun;46(6):850-7. doi: 10.1016/j.yjmcc.2009.02.007. Epub 2009 Feb 20.
Uncontrolled cell death is a fundamental cause of organ disease in humans. However, despite the need for us to delineate the molecular machinery that underlies cardiomyocyte death, our knowledge of these lethal cellular processes is still limited. The discovery that mitochondrial dysfunction, and in particular the mitochondrial permeability transition (MPT) pore, is often a common cause of the cardiac cell mortality that underlies numerous cardiac diseases has been a first crucial step. The purpose of this review is to outline our current understanding of the molecular identity of the MPT pore and the many questions that still need to be answered.
不受控制的细胞死亡是人类器官疾病的一个根本原因。然而，尽管我们需要描绘出心肌细胞死亡背后的分子机制，但我们对这些致命细胞过程的了解仍然有限。线粒体功能障碍，尤其是线粒体通透性转换（MPT）孔，往往是众多心脏疾病所导致的心肌细胞死亡的常见原因，这一发现是关键的第一步。本综述的目的是概述我们目前对MPT孔分子特性的理解以及仍需解答的诸多问题。
