van der Lugt J J, Nel P W, Kitching J P
Veterinary Research Institute, Onderstepoort.
Onderstepoort J Vet Res. 1991 Sep;58(3):211-21.
The clinical features and pathological findings of 6 steers drenched with dried plant material of Cestrum laevigatum are described. Doses ranging from 0.5 to 10 g/kg/day were given intraruminally for 1 to 38 days. Animals that received 5 to 10 g/kg/day showed nervous signs including ataxia, muscle tremors, hypersensitivity and intermittent chewing. Clinical signs in the steers which received 0,5 to 4 g/kg/day were mild. High doses induced moderate to severe hepatosis characterized by centrilobular to midzonal coagulative necrosis, haemorrhage and congestion. At lower rates only mild hepatic lesions, characterized by disappearance of hepatocytes and collapse of the reticulin stroma in the centrilobular areas were evident. Ultrastructural changes were primarily limited to the hepatocytes and comprised degeneration, necrosis and fatty change. Degeneration and necrosis of endothelial cells and disruption of sinusoidal walls were occasionally observed.
描述了6头用平滑夜香树干燥植物材料灌服的公牛的临床特征和病理发现。瘤胃内给药剂量为0.5至10克/千克/天，持续1至38天。接受5至10克/千克/天剂量的动物出现神经症状，包括共济失调、肌肉震颤、过敏和间歇性咀嚼。接受0.5至4克/千克/天剂量的公牛临床症状较轻。高剂量导致中度至重度肝病，其特征为小叶中心至中间带的凝固性坏死、出血和充血。较低剂量时，仅可见轻度肝脏病变，其特征为小叶中心区域肝细胞消失和网状纤维基质塌陷。超微结构变化主要局限于肝细胞，包括变性、坏死和脂肪变性。偶尔观察到内皮细胞变性和坏死以及窦壁破坏。
