Liu Jie, Tamura Sadaaki, Kurashiki Kenji, Shimizu Kuniyoshi, Noda Kiyoshi, Konishi Fumiko, Kumamoto Shoichiro, Kondo Ryuichiro
Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Chem Biodivers. 2009 Feb;6(2):231-43. doi: 10.1002/cbdv.200800019.
The 30% EtOH extracts of Ganoderma lucidum Fr. Karst (Ganodermateceae) showed weak 5alpha-reductase inhibitory activity and binding ability to androgen receptor. When LNCaP (lymph-node carcinoma of the prostate) cells were treated with the EtOH extracts, cell proliferation was inhibited. Treatment with the extracts significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer. From the 30% EtOH extracts, we isolated ganoderiol F, which showed binding activity to androgen receptor and inhibited LNCaP cell proliferation, as one of the active compounds in the 30% EtOH extracts.
灵芝（多孔菌科）的30%乙醇提取物显示出较弱的5α-还原酶抑制活性以及与雄激素受体的结合能力。当用乙醇提取物处理LNCaP（前列腺淋巴结癌）细胞时，细胞增殖受到抑制。提取物处理显著抑制了去势大鼠中睾酮诱导的前列腺腹侧叶生长。这些结果表明，灵芝可能是治疗雄激素诱导疾病（如良性前列腺增生或前列腺癌）的有用成分。从30%乙醇提取物中，我们分离出了灵芝二醇F，它显示出与雄激素受体的结合活性并抑制LNCaP细胞增殖，是30%乙醇提取物中的活性化合物之一。
