Liu Jie, Shiono Jun, Shimizu Kuniyoshi, Kukita Akiko, Kukita Toshio, Kondo Ryuichiro
Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Bioorg Med Chem Lett. 2009 Apr 15;19(8):2154-7. doi: 10.1016/j.bmcl.2009.02.119. Epub 2009 Mar 4.
Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.
前列腺癌是西方国家男性中最常见的癌症，骨转移发生率很高。从灵芝乙醇提取物中分离出的具有5α-还原酶抑制和雄激素受体（AR）结合活性的灵芝酸DM，可以抑制前列腺癌细胞生长并阻断破骨细胞生成。
