Tarachowski M L, Saitzewa N J, Mosalewsky A F, Grabowaja A R
Kinderkliniken Wissenschaftlichen Forschungsinstituts für Pädiatrie, Geburtshilfe und Gynäkologie, Kiew, UdSSR.
Padiatr Grenzgeb. 1991;30(4):327-34.
The possibility to forecast pharmacotherapeutic effect in children with chronic diseases of breathing and digestion was studied. It was established that the use of pathogenic and associative markers, characteristic of the background state of a child as compared to individual peculiarities of pharmacokinetics and pharmacodynamics of a certain drug, will allow to forecast the efficiency of drug treatment of chronic diseases of breathing organs (bronchitis, pneumonia, asthmatic bronchitis) and digestion (gastritis, cholecystocholangitis). The use of aminophenazone marker in children with above mentioned pathology became the basis of research into efficiency of spasmolytics with similar type of metabolism (papaverini hydrochloridum, aminophyllinum, drotaverinum). Mathematic models of spasmolytics efficiency forecast was developed by many factor computer analysis.
对预测患有呼吸和消化系统慢性病儿童的药物治疗效果的可能性进行了研究。已确定，与某种药物的药代动力学和药效学的个体特性相比，利用作为儿童背景状态特征的致病和关联标志物，将能够预测呼吸器官（支气管炎、肺炎、哮喘性支气管炎）和消化系统（胃炎、胆囊胆管炎）慢性病的药物治疗效果。在患有上述病症的儿童中使用氨基比林标志物，成为了对具有类似代谢类型的解痉药（盐酸罂粟碱、氨茶碱、屈他维林）疗效研究的基础。通过多因素计算机分析建立了解痉药疗效预测的数学模型。
