Cederquist Kristin B, Keating Christine D
Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
ACS Nano. 2009 Feb 24;3(2):256-60. doi: 10.1021/nn9000726.
DNA-coated Au nanoparticles have myriad applications as versatile building blocks in nanomaterials assembly, powerful amplification tags for bioanalysis, and promising new approaches to medical therapeutics. Characterization, control, and a thorough understanding of the DNA surface interface are essential in the development of these conjugates. A new paper in this issue explores the impact of nanosphere diameter on DNA adsorption and demonstrates that particle curvature plays an important role in controlling the DNA surface density. The study proposes a model that can be used to predict DNA packing on nonspherical particles and validates it using Au nanorods. This work paves the way for improved understanding of the DNA:Au interface in these versatile bioconjugates.
DNA包覆的金纳米颗粒作为纳米材料组装中通用的构建单元、生物分析中强大的扩增标签以及医学治疗领域有前景的新方法,有着众多应用。对这些缀合物的开发而言,DNA表面界面的表征、控制及透彻理解至关重要。本期的一篇新论文探讨了纳米球直径对DNA吸附的影响,并证明颗粒曲率在控制DNA表面密度方面起着重要作用。该研究提出了一个可用于预测非球形颗粒上DNA堆积情况的模型,并使用金纳米棒对其进行了验证。这项工作为更好地理解这些多功能生物缀合物中的DNA:Au界面铺平了道路。